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There is another melanocyte-stimulating hormone called B-melanotropin. Cleavage of 3-melanotropin with trypsin produces the following peptides plus free aspartic acid. WGSPPK, DSGPYK, MEHFR Part A If you assume maximum sequence similarity between a-melanotropin and 3-melanotropin, then what must the sequence of the latter be? (a -melanotropin: Ser- Tyr- Ser-Met- Glu- His- Phe- Arg- Trp- Gly- Lys- Pro- Val) Drag the appropriate labels to their respective targets so that the maximum sequence similarity to the order of a-melanotropin will be shown. MEHFR WGSPPK DSGPYK Reset Help

There is another melanocyte-stimulating hormone called B-melanotropin. Cleavage of 3-melanotropin with trypsin produces the following peptides plus free aspartic acid. WGSPPK, DSGPYK, MEHFR Part A If you assume maximum sequence similarity between a-melanotropin and 3-melanotropin, then what must the sequence of the latter be? (a -melanotropin: Ser- Tyr- Ser-Met- Glu- His- Phe- Arg- Trp- Gly- Lys- Pro- Val) Drag the appropriate labels to their respective targets so that the maximum sequence similarity to the order of a-melanotropin will be shown. MEHFR WGSPPK DSGPYK Reset Help

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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52.18.1

### Understanding Melanocyte-Stimulating Hormones **Context:** This exercise involves understanding the relationship between two hormones, α-melanotropin and β-melanotropin, focusing on their amino acid sequences. #### Melanotropin Hormones - **α-Melanotropin Sequence:** Ser—Tyr—Ser—Met—Glu—His—Phe—Arg—Trp—Gly—Lys—Pro—Val - **β-Melanotropin Peptides:** After cleavage with trypsin, β-melanotropin produces three peptides: - WGSPPK - DSGPYK - MEHFR #### Task: To achieve maximum sequence similarity between α-melanotropin and β-melanotropin, determine the sequence arrangement of β-melanotropin. **Interactive Activity:** You are provided with an interface displaying three labeled tiles: MEHFR, WGSPPK, and DSGPYK. Each label represents a peptide derived from β-melanotropin. Your task is to drag and arrange these peptides in the sequence order that best matches the α-melanotropin sequence. **Instructions:** 1. **Analyze each peptide fragment:** - MEHFR - WGSPPK - DSGPYK 2. **Consider the amino acid composition:** Compare these fragments to the full α-melanotropin sequence to determine the most logical order. 3. **Use the interface:** Drag the labels into the designated boxes to align them in the order of maximum sequence similarity. 4. **Utilize tools:** There are options to reset your arrangement or use a help function for guidance. **Objective:** This task aims to deepen your understanding of peptide structure-function relationships by comparing the sequence homology between two related hormones, gaining insight into protein interaction and function in biological systems.
Transcribed Image Text:### Understanding Melanocyte-Stimulating Hormones **Context:** This exercise involves understanding the relationship between two hormones, α-melanotropin and β-melanotropin, focusing on their amino acid sequences. #### Melanotropin Hormones - **α-Melanotropin Sequence:** Ser—Tyr—Ser—Met—Glu—His—Phe—Arg—Trp—Gly—Lys—Pro—Val - **β-Melanotropin Peptides:** After cleavage with trypsin, β-melanotropin produces three peptides: - WGSPPK - DSGPYK - MEHFR #### Task: To achieve maximum sequence similarity between α-melanotropin and β-melanotropin, determine the sequence arrangement of β-melanotropin. **Interactive Activity:** You are provided with an interface displaying three labeled tiles: MEHFR, WGSPPK, and DSGPYK. Each label represents a peptide derived from β-melanotropin. Your task is to drag and arrange these peptides in the sequence order that best matches the α-melanotropin sequence. **Instructions:** 1. **Analyze each peptide fragment:** - MEHFR - WGSPPK - DSGPYK 2. **Consider the amino acid composition:** Compare these fragments to the full α-melanotropin sequence to determine the most logical order. 3. **Use the interface:** Drag the labels into the designated boxes to align them in the order of maximum sequence similarity. 4. **Utilize tools:** There are options to reset your arrangement or use a help function for guidance. **Objective:** This task aims to deepen your understanding of peptide structure-function relationships by comparing the sequence homology between two related hormones, gaining insight into protein interaction and function in biological systems.
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