The striatum has an (excitatory/inhibitory) connection to the globus pallidus external.  Activation of that connection (increases/decreases) activity in the globus pallidus internal, ultimately (promoting/suppressing) movement. Group of answer choices Excitatory, increases, promoting Excitatory, increases, suppressing Inhibitory, decreases, promoting Inhibitory, decreases, suppressing Inhibitory, increases, suppressing

Human Anatomy & Physiology (11th Edition)
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The striatum has an (excitatory/inhibitory) connection to the globus pallidus external.  Activation of that connection (increases/decreases) activity in the globus pallidus internal, ultimately (promoting/suppressing) movement.
Group of answer choices
Excitatory, increases, promoting
Excitatory, increases, suppressing
Inhibitory, decreases, promoting
Inhibitory, decreases, suppressing
Inhibitory, increases, suppressing

 

Is my reasoning correct?

 

basal ganglia circuitry:

  1. The striatum (caudate nucleus and putamen) sends inhibitory projections to the globus pallidus externus (GPe). Therefore, the connection between the striatum and GPe is inhibitory.

  2. The GPe sends inhibitory projections to the subthalamic nucleus (STN).

  3. The STN sends excitatory projections to the globus pallidus internus (GPi).

  4. The GPi, in turn, sends inhibitory projections to the thalamus.

When the striatum activates its connection to the GPe (due to receiving excitatory input from the cortex), it inhibits the GPe. This reduces the inhibitory influence of the GPe on the STN, which means the STN becomes more active and sends more excitatory signals to the GPi. This results in the GPi increasing its inhibitory output to the thalamus. Since the thalamus sends excitatory projections to the cortex to promote movement, increased inhibition of the thalamus suppresses movement.

Based on this explanation:

  • The striatum has an inhibitory connection to the globus pallidus external.
  • Activation of that connection increases activity in the globus pallidus internal.
  • This ultimately suppresses movement.

So, the correct group of answer choices is: Inhibitory, increases, suppressing.

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