The striatum has an (excitatory/inhibitory) connection to the globus pallidus external.  Activation of that connection (increases/decreases) activity in the globus pallidus internal, ultimately (promoting/suppressing) movement. Group of answer choices Excitatory, increases, promoting Excitatory, increases, suppressing Inhibitory, decreases, promoting Inhibitory, decreases, suppressing Inhibitory, increases, suppressing

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
icon
Concept explainers
Question
100%

The striatum has an (excitatory/inhibitory) connection to the globus pallidus external.  Activation of that connection (increases/decreases) activity in the globus pallidus internal, ultimately (promoting/suppressing) movement.
Group of answer choices
Excitatory, increases, promoting
Excitatory, increases, suppressing
Inhibitory, decreases, promoting
Inhibitory, decreases, suppressing
Inhibitory, increases, suppressing

 

Is my reasoning correct?

 

basal ganglia circuitry:

  1. The striatum (caudate nucleus and putamen) sends inhibitory projections to the globus pallidus externus (GPe). Therefore, the connection between the striatum and GPe is inhibitory.

  2. The GPe sends inhibitory projections to the subthalamic nucleus (STN).

  3. The STN sends excitatory projections to the globus pallidus internus (GPi).

  4. The GPi, in turn, sends inhibitory projections to the thalamus.

When the striatum activates its connection to the GPe (due to receiving excitatory input from the cortex), it inhibits the GPe. This reduces the inhibitory influence of the GPe on the STN, which means the STN becomes more active and sends more excitatory signals to the GPi. This results in the GPi increasing its inhibitory output to the thalamus. Since the thalamus sends excitatory projections to the cortex to promote movement, increased inhibition of the thalamus suppresses movement.

Based on this explanation:

  • The striatum has an inhibitory connection to the globus pallidus external.
  • Activation of that connection increases activity in the globus pallidus internal.
  • This ultimately suppresses movement.

So, the correct group of answer choices is: Inhibitory, increases, suppressing.

Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps

Blurred answer
Knowledge Booster
Tissue system
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education