The protein p53 is activated by a number of stresses on the cell, including DNA damage (as shown in this figure); Oncogenic Signaling DNA Damage Hypoxia Nutrient Deficiency Senescence DIDADE DNA Repair Autophagy Ferroptosis p53 STOP G2 Cell Cycle Arrest Oxidative Stress Hormones Programmed death Apoptosis Physiological processes Necrosis Metabolic switch Cellular differentiation Necroptosis Dormancy When the cell's DNA is damaged, p53 helps to arrest the cell cycle in G1, allowing time for the cell to repair its DNA before replicating. p53 does this job by stimulating the synthesis of a protein that inhibits the cyclin-dependent kinase. A. Mutations that inactivate p53 contribute to 50% of human cancers. Would you classify p53 as a tumor-suppressor gene or a proto-oncogene? Explain your answer. B. Suppose that a cell receives a signal to proceed past the p53 arrest and, at the same time, is treated with doxorubicin, a drug that inhibits DNA synthesis. Will this cell continue through the cell cycle and produce two normal daughter cells? Explain your answer.
The protein p53 is activated by a number of stresses on the cell, including DNA damage (as shown in this figure); Oncogenic Signaling DNA Damage Hypoxia Nutrient Deficiency Senescence DIDADE DNA Repair Autophagy Ferroptosis p53 STOP G2 Cell Cycle Arrest Oxidative Stress Hormones Programmed death Apoptosis Physiological processes Necrosis Metabolic switch Cellular differentiation Necroptosis Dormancy When the cell's DNA is damaged, p53 helps to arrest the cell cycle in G1, allowing time for the cell to repair its DNA before replicating. p53 does this job by stimulating the synthesis of a protein that inhibits the cyclin-dependent kinase. A. Mutations that inactivate p53 contribute to 50% of human cancers. Would you classify p53 as a tumor-suppressor gene or a proto-oncogene? Explain your answer. B. Suppose that a cell receives a signal to proceed past the p53 arrest and, at the same time, is treated with doxorubicin, a drug that inhibits DNA synthesis. Will this cell continue through the cell cycle and produce two normal daughter cells? Explain your answer.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:The protein p53 is activated by a number of stresses on the cell, including DNA damage (as shown in this figure);
Oncogenic Signaling
DNA Damage
Hypoxia
Nutrient Deficiency
Senescence
DIDADE
DNA Repair
Autophagy
Ferroptosis
p53
STOP
G2
Oxidative Stress
Hormones
Cell Cycle Arrest
Programmed death
Apoptosis
Physiological
processes
Necrosis
Metabolic switch
Cellular differentiation
Necroptosis
Dormancy
When the cell's DNA is damaged, p53 helps to arrest the cell cycle in G1, allowing time for the cell to repair its DNA before
replicating. p53 does this job by stimulating the synthesis of a protein that inhibits the cyclin-dependent kinase.
A. Mutations that inactivate p53 contribute to 50% of human cancers. Would you classify p53 as a tumor-suppressor gene or a
proto-oncogene? Explain your answer.
B. Suppose that a cell receives a signal to proceed past the p53 arrest and, at the same time, is treated with doxorubicin, a drug
that inhibits DNA synthesis. Will this cell continue through the cell cycle and produce two normal daughter cells? Explain your
answer.
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