The Organic Chemistry of Life Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are shown. 1. A step in glycolysis (the metabolism of glucose and other sugars). OH PO, OH PO. OP OP Dihydroxyacetone phosphate (DHAP) OH OH Glyceraldehyde 3-phosphate (G3P) Fructose 1,6-bisphosphate

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### The Organic Chemistry of Life

#### Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are shown.

---

#### 1. A step in glycolysis (the metabolism of glucose and other sugars)

The diagram illustrates a chemical transformation in the glycolytic pathway.

- **Starting molecule**: Fructose 1,6-bisphosphate

  **Structure**:
  ```
     O  OH
     |   |
     P-O-C-C-C-C-C-OP
          |   |   |
         OH  OH  OH
  ```

- **Products**: 

  1. **Dihydroxyacetone phosphate (DHAP)**
     ```
       PO
       |
       C
       |
       C=O
       |
      OH
     ```
  
  2. **Glyceraldehyde 3-phosphate (G3P)**
     ```
       O
       ||
       C
       |
       H-C-O-P
       |
       OH
     ```

The diagrams to the right illustrate the cleavage of Fructose 1,6-bisphosphate to form two three-carbon molecules, dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). This step is crucial in glycolysis, as it splits a six-carbon molecule into two three-carbon molecules, each of which can continue through the glycolytic pathway to eventually produce ATP.

---

This section is aimed at providing a clear understanding of one of the key breakdown processes in the glycolytic pathway. Students are encouraged to delve deeper into each molecular structure to understand the transformations and significance within cellular metabolism.
Transcribed Image Text:### The Organic Chemistry of Life #### Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are shown. --- #### 1. A step in glycolysis (the metabolism of glucose and other sugars) The diagram illustrates a chemical transformation in the glycolytic pathway. - **Starting molecule**: Fructose 1,6-bisphosphate **Structure**: ``` O OH | | P-O-C-C-C-C-C-OP | | | OH OH OH ``` - **Products**: 1. **Dihydroxyacetone phosphate (DHAP)** ``` PO | C | C=O | OH ``` 2. **Glyceraldehyde 3-phosphate (G3P)** ``` O || C | H-C-O-P | OH ``` The diagrams to the right illustrate the cleavage of Fructose 1,6-bisphosphate to form two three-carbon molecules, dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). This step is crucial in glycolysis, as it splits a six-carbon molecule into two three-carbon molecules, each of which can continue through the glycolytic pathway to eventually produce ATP. --- This section is aimed at providing a clear understanding of one of the key breakdown processes in the glycolytic pathway. Students are encouraged to delve deeper into each molecular structure to understand the transformations and significance within cellular metabolism.
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