The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma were obtained experimentally at various temperatures (T) and pH values. The results are presented in the following table: pH=6.25 pH=7.0 pH=7.25 T= 27 C 0.24 0.72 0.89 T= 30 C 0.31 0.84 1.06 T= 40 C 1.23 27.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and then partitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in water after in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place) 1.49 Answer: 19.01
The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma were obtained experimentally at various temperatures (T) and pH values. The results are presented in the following table: pH=6.25 pH=7.0 pH=7.25 T= 27 C 0.24 0.72 0.89 T= 30 C 0.31 0.84 1.06 T= 40 C 1.23 27.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and then partitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in water after in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place) 1.49 Answer: 19.01
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma were
obtained experimentally at various temperatures (T) and pH values. The results are presented in the
following table:
pH=7.0
0.72
0.84
pH=6.25
pH=7.25
T= 27 C
0.24
0.89
T= 30 C
0.31
1.06
T= 40 C
1.23
1.49
27.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and then
partitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in water
after in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place)
Answer: 19.01
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