The Na-glucose symport system of intestinal epithelial cells couples the \"downhill\" transport of two Na ions into the cell to the \"uphill\" transport of glucose, pumping glucose into the cell against its concentration gradient. If the Na concentration outside the cell ([Na+] out) is 149 mm and that inside the cell ([Na+]in) is 19.0 mM, and the cell potential is -49.0 mV (inside negative), calculate the maximum ratio of [glucose]in to [glucose]out that could theoretically be produced if the energy coupling were 100% efficient. Assume the temperature is 37 °C.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The Na–glucose symport system of intestinal epithelial cells couples the "downhill" transport of two Na ions into the cell to the "uphill" transport of glucose, pumping glucose into the cell against its concentration gradient. If the Na concentration outside the cell \([ \text{[Na}^+]_{\text{out}} ]\) is 149 mM and that inside the cell \([ \text{[Na}^+]_{\text{in}} ]\) is 19.0 mM, and the cell potential is -49.0 mV (inside negative), calculate the maximum ratio of \([\text{glucose}]_{\text{in}}\) to \([\text{glucose}]_{\text{out}}\) that could theoretically be produced if the energy coupling were 100% efficient. Assume the temperature is 37 °C.
Transcribed Image Text:The Na–glucose symport system of intestinal epithelial cells couples the "downhill" transport of two Na ions into the cell to the "uphill" transport of glucose, pumping glucose into the cell against its concentration gradient. If the Na concentration outside the cell \([ \text{[Na}^+]_{\text{out}} ]\) is 149 mM and that inside the cell \([ \text{[Na}^+]_{\text{in}} ]\) is 19.0 mM, and the cell potential is -49.0 mV (inside negative), calculate the maximum ratio of \([\text{glucose}]_{\text{in}}\) to \([\text{glucose}]_{\text{out}}\) that could theoretically be produced if the energy coupling were 100% efficient. Assume the temperature is 37 °C.
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