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The Levaquin treatment caused a mutation to develop in the resistant cells Population replacement of normal flora wtih Levaquin resistant cells due to loss of competition

The Levaquin treatment caused a mutation to develop in the resistant cells Population replacement of normal flora wtih Levaquin resistant cells due to loss of competition

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Use the following to answer 4 consecutive questions Case History: A patient is admitted to the Emergency Department with a 3 day history of severe coughing and fever, then is transferred to the ICU with severe bacterial pneumonia (lung infection) caused by Streptococcus pneumoniae. The patient is placed on the fluoroquinolone antibiotic Levaquin (R) and initially improves, however the patient relapses and dies on day 5 of hospitalization. Two cultures were performed at day 1 and 5. The isolates are identical with the exception that the S. pneumoniae cultured from day 1 has a point mutation in the parC gene and is susceptible to Levaquin while the S. pneumoniae cultured from day 5 has point mutations in both the parC and gyrA genes and is resistant to Levaquin. The patient dies on day 5 from pneumonia and sepsis
Transcribed Image Text:Use the following to answer 4 consecutive questions Case History: A patient is admitted to the Emergency Department with a 3 day history of severe coughing and fever, then is transferred to the ICU with severe bacterial pneumonia (lung infection) caused by Streptococcus pneumoniae. The patient is placed on the fluoroquinolone antibiotic Levaquin (R) and initially improves, however the patient relapses and dies on day 5 of hospitalization. Two cultures were performed at day 1 and 5. The isolates are identical with the exception that the S. pneumoniae cultured from day 1 has a point mutation in the parC gene and is susceptible to Levaquin while the S. pneumoniae cultured from day 5 has point mutations in both the parC and gyrA genes and is resistant to Levaquin. The patient dies on day 5 from pneumonia and sepsis
The patient initially improved with Levaquin treatment with a decrease in symptom severity by day 3 of hospitalization. On day 4, the patient's temperature increased to 104.5°F with progressive hypoxia and hypotension. The patient died on day 5 of hospitalization. Which of the following explain why the patient died The Levaquin treatment caused a mutation to develop in the resistant cells Population replacement of normal flora wtih Levaquin resistant cells due to loss of competition Population increase of Levaquin susceptible cells due to increased nutrients on day 5 Levaquin treatment resulted in population replacement of susceptible cells with resistant cells by day 5
Transcribed Image Text:The patient initially improved with Levaquin treatment with a decrease in symptom severity by day 3 of hospitalization. On day 4, the patient's temperature increased to 104.5°F with progressive hypoxia and hypotension. The patient died on day 5 of hospitalization. Which of the following explain why the patient died The Levaquin treatment caused a mutation to develop in the resistant cells Population replacement of normal flora wtih Levaquin resistant cells due to loss of competition Population increase of Levaquin susceptible cells due to increased nutrients on day 5 Levaquin treatment resulted in population replacement of susceptible cells with resistant cells by day 5
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