The Km parameter in the Michaelis-Menton-like formulae can be defined as: a. the rate constants for decomposition of ES divided by the rate constant for decomposition of E b. the concentration of substrate that gives 50% Vmax c. the concentration of products that give constant velocity
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
The Km parameter in the Michaelis-Menton-like formulae can be defined as:
the rate constants for decomposition of ES divided by the rate constant for decomposition of E
the concentration of substrate that gives 50% Vmax
the concentration of products that give constant velocity
the concentration of substrate corresponding to rate constants for decomposition of ES
the rate constant for formation of ES divided by the rate constant for formation of product
To derive the definition of Km, we would use Michaelis-Menton formula .
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