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The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 | T X 10-8 Hormone concentration (M) 10-6 10-4 N 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? M M M

The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 | T X 10-8 Hormone concentration (M) 10-6 10-4 N 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? M M M

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? OX ΟΥ ΟΖ O X, Y, and Z have the same affinity Measuring adenylate cyclase activity as a function of hormone concentration reveals whether the hormone-receptor complex stimulates the adenylate cyclase cascade. The results of this experiment are shown in the graph that plots percentage adenylate cyclase activity against hormone concentration. Stimulation of adenylate cyclase as a percentage of maximum 100 80 60 40 20 X 10-6 Y 10-8 Hormone concentration (M) 10-4 Z ○ Unlike that of X and Y, the hormone-receptor complex for Z does not stimulate adenylate cyclase. O Only the hormone-receptor complex for X leads to adenylate cyclase stimulation. O All of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation. 10-² Considering the relative binding affinities and adenylate cyclase activity as a function of hormone concentration, what can you conclude about the mechanism of action of the hormone-receptor complexes? O None of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation.
Transcribed Image Text:Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? OX ΟΥ ΟΖ O X, Y, and Z have the same affinity Measuring adenylate cyclase activity as a function of hormone concentration reveals whether the hormone-receptor complex stimulates the adenylate cyclase cascade. The results of this experiment are shown in the graph that plots percentage adenylate cyclase activity against hormone concentration. Stimulation of adenylate cyclase as a percentage of maximum 100 80 60 40 20 X 10-6 Y 10-8 Hormone concentration (M) 10-4 Z ○ Unlike that of X and Y, the hormone-receptor complex for Z does not stimulate adenylate cyclase. O Only the hormone-receptor complex for X leads to adenylate cyclase stimulation. O All of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation. 10-² Considering the relative binding affinities and adenylate cyclase activity as a function of hormone concentration, what can you conclude about the mechanism of action of the hormone-receptor complexes? O None of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation.
The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 X 10-6 Y 10-4 Z 10-8 Hormone concentration (M) 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? Ox M M M
Transcribed Image Text:The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 X 10-6 Y 10-4 Z 10-8 Hormone concentration (M) 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? Ox M M M
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