The graph below shows the hemoglobin dissociation curves (also called equilibrium curves) for normal blood pH (the blue curve) and two other conditions. 100+ 92 O₂ saturation of hemoglobin (%) 80 69 60 56 43 40 20 0 0 20 30 normal blood pH -in exercising tissues 40 60 80 100 Po₂ (mm Hg) Adapted from Biology by Campbell and Reece ©2008 Pearson Education, Inc. - in lungs Given what you know about the Bohr shift, what is the difference in O₂ saturation of hemoglobin in the lungs versus hemoglobin in exercising tissues, as represented on this graph? Keep in mind that the pH of blood in the lungs is not the same as the pH of blood in exercising tissues.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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7l.4.3

**Part C - The Bohr Shift**

The graph below shows the hemoglobin dissociation curves (also called equilibrium curves) for normal blood pH (the blue curve) and two other conditions.

![Graph of Hemoglobin Dissociation Curves](https://example.com/graph)

**Graph Explanation:**

The graph displays three curves representing the percentage saturation of hemoglobin with oxygen (y-axis) against the partial pressure of oxygen (P_O2 in mm Hg) on the x-axis.

- **Blue Curve:** Represents the hemoglobin dissociation curve at normal blood pH.
- **Green Curve:** Represents hemoglobin at a higher pH typically found in the lungs, showing higher saturation at specific P_O2 values.
- **Red Curve:** Represents hemoglobin at a lower pH found in exercising tissues, showing lower saturation at the same P_O2.

Key points on the graph:
- At P_O2 of 100 mm Hg (representing conditions in the lungs), the saturation is about 98% in normal blood pH.
- In exercising tissues (lower pH), at P_O2 of around 20 mm Hg, the saturation drops significantly to about 43%.
- The difference in O_2 saturation between the lungs and exercising tissues is shown by the differences in the saturation percentages at their respective P_O2 levels.

**Question:**
Given what you know about the Bohr shift, what is the difference in O_2 saturation of hemoglobin in the lungs versus hemoglobin in exercising tissues, as represented on this graph? Keep in mind that the pH of blood in the lungs is not the same as the pH of blood in exercising tissues.

**Instructions:**
Express your answer in percent, but do not include the percent sign in your answer.

*[Adapted from Biology by Campbell and Reece © 2008 Pearson Education, Inc.]*
Transcribed Image Text:**Part C - The Bohr Shift** The graph below shows the hemoglobin dissociation curves (also called equilibrium curves) for normal blood pH (the blue curve) and two other conditions. ![Graph of Hemoglobin Dissociation Curves](https://example.com/graph) **Graph Explanation:** The graph displays three curves representing the percentage saturation of hemoglobin with oxygen (y-axis) against the partial pressure of oxygen (P_O2 in mm Hg) on the x-axis. - **Blue Curve:** Represents the hemoglobin dissociation curve at normal blood pH. - **Green Curve:** Represents hemoglobin at a higher pH typically found in the lungs, showing higher saturation at specific P_O2 values. - **Red Curve:** Represents hemoglobin at a lower pH found in exercising tissues, showing lower saturation at the same P_O2. Key points on the graph: - At P_O2 of 100 mm Hg (representing conditions in the lungs), the saturation is about 98% in normal blood pH. - In exercising tissues (lower pH), at P_O2 of around 20 mm Hg, the saturation drops significantly to about 43%. - The difference in O_2 saturation between the lungs and exercising tissues is shown by the differences in the saturation percentages at their respective P_O2 levels. **Question:** Given what you know about the Bohr shift, what is the difference in O_2 saturation of hemoglobin in the lungs versus hemoglobin in exercising tissues, as represented on this graph? Keep in mind that the pH of blood in the lungs is not the same as the pH of blood in exercising tissues. **Instructions:** Express your answer in percent, but do not include the percent sign in your answer. *[Adapted from Biology by Campbell and Reece © 2008 Pearson Education, Inc.]*
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