The following is an assignment question I wrote and then submitted to a couple of different Al chatbots: a poly-lysine peptide can form an alpha helix at pH 11.6 but not at pH 7.4, why? Here is the response one of the Al bots gave me: "The ability of a polypeptide to form an alpha helix is influenced by its amino acid composition and the environment in which it exists, particularly the pH. At pH 11.6, the environment is highly basic, favoring the deprotonation of amino acids. In the case of lysine, which has an amino group with a pKa around 10.5, it exists predominantly in its deprotonated form (positively charged) at pH 11.6. This deprotonation leads to increased electrostatic repulsion between adjacent positively charged amino groups along the polypeptide chain. As a result, the polypeptide chain adopts a more extended conformation, which can favor the formation of alpha helices. Additionally, the basic environment may promote hydrogen bonding interactions between the amino acid residues, further stabilizing the alpha helix structure. However, at pH 7.4, which is closer to physiological pH, the lysine residues are more likely to be protonated due to the lower pH. In this protonated state, electrostatic repulsion between positively charged amino groups is reduced, and the polypeptide chain may adopt a more compact or random coil conformation rather than forming an alpha helix. Additionally, the hydrogen bonding interactions that stabilize the alpha helix may be disrupted due to the less favorable pH environment. Therefore, the difference in pH between pH 11.6 and pH 7.4 leads to differences in the protonation state of lysine residues and the overall electrostatic and hydrogen bonding interactions within the polypeptide chain, resulting in the formation of an alpha helix at pH 11.6 but not at pH 7.4." If you want, you can make an account and try submitted the same question to an Al bot (optional). Al bots are always being updated, they access previous text in your conversation, and are sensitive to differences in text formatting, but you will probably get a somewhat similar response. The response above that the Al gave me contains several errors. These errors include incorrect facts and incorrect implications about protein structure and amino acids. Analyze the response the Al gave me and identify 5 different errors that the Al made. For each sentence that you identify that contains an error you should: Clearly explain the biochemical nature of all the errors in the sentence. Note that there may be more than one error in a sentence. You should make sure to also explain how the errors could be corrected. Note that some of the errors in the answer are implied and not directly stated. So you should think about the 2280 course content carefully when composing your answer. When answering: for each error that you identify copy and paste the sentence of the Al response as a quote into your answer. Then below the Al error you have identified give your answer. You should not identify any simple spelling/terminology errors when answering.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Please find all 5 mistakes and provide corrections for all 5 mistakes

The following is an assignment question I wrote and then submitted to a couple of different Al chatbots:
a poly-lysine peptide can form an alpha helix at pH 11.6 but not at pH 7.4, why?
Here is the response one of the Al bots gave me:
"The ability of a polypeptide to form an alpha helix is influenced by its amino acid composition and the
environment in which it exists, particularly the pH.
At pH 11.6, the environment is highly basic, favoring the deprotonation of amino acids. In the case of
lysine, which has an amino group with a pKa around 10.5, it exists predominantly in its deprotonated form
(positively charged) at pH 11.6. This deprotonation leads to increased electrostatic repulsion between
adjacent positively charged amino groups along the polypeptide chain. As a result, the polypeptide chain
adopts a more extended conformation, which can favor the formation of alpha helices. Additionally, the
basic environment may promote hydrogen bonding interactions between the amino acid residues, further
stabilizing the alpha helix structure.
However, at pH 7.4, which is closer to physiological pH, the lysine residues are more likely to be
protonated due to the lower pH. In this protonated state, electrostatic repulsion between positively charged
amino groups is reduced, and the polypeptide chain may adopt a more compact or random coil
conformation rather than forming an alpha helix. Additionally, the hydrogen bonding interactions that
stabilize the alpha helix may be disrupted due to the less favorable pH environment.
Therefore, the difference in pH between pH 11.6 and pH 7.4 leads to differences in the protonation state of
lysine residues and the overall electrostatic and hydrogen bonding interactions within the polypeptide
chain, resulting in the formation of an alpha helix at pH 11.6 but not at pH 7.4."
If you want, you can make an account and try submitted the same question to an Al bot (optional). Al bots
are always being updated, they access previous text in your conversation, and are sensitive to differences
in text formatting, but you will probably get a somewhat similar response.
The response above that the Al gave me contains several errors. These errors include incorrect facts
and incorrect implications about protein structure and amino acids.
Analyze the response the Al gave me and identify 5 different errors that the Al made. For each
sentence that you identify that contains an error you should: Clearly explain the biochemical nature of all
the errors in the sentence. Note that there may be more than one error in a sentence. You should make
sure to also explain how the errors could be corrected. Note that some of the errors in the answer are
implied and not directly stated. So you should think about the 2280 course content carefully when
composing your answer.
When answering: for each error that you identify copy and paste the sentence of the Al response as a
quote into your answer. Then below the Al error you have identified give your answer. You should not
identify any simple spelling/terminology errors when answering.
Transcribed Image Text:The following is an assignment question I wrote and then submitted to a couple of different Al chatbots: a poly-lysine peptide can form an alpha helix at pH 11.6 but not at pH 7.4, why? Here is the response one of the Al bots gave me: "The ability of a polypeptide to form an alpha helix is influenced by its amino acid composition and the environment in which it exists, particularly the pH. At pH 11.6, the environment is highly basic, favoring the deprotonation of amino acids. In the case of lysine, which has an amino group with a pKa around 10.5, it exists predominantly in its deprotonated form (positively charged) at pH 11.6. This deprotonation leads to increased electrostatic repulsion between adjacent positively charged amino groups along the polypeptide chain. As a result, the polypeptide chain adopts a more extended conformation, which can favor the formation of alpha helices. Additionally, the basic environment may promote hydrogen bonding interactions between the amino acid residues, further stabilizing the alpha helix structure. However, at pH 7.4, which is closer to physiological pH, the lysine residues are more likely to be protonated due to the lower pH. In this protonated state, electrostatic repulsion between positively charged amino groups is reduced, and the polypeptide chain may adopt a more compact or random coil conformation rather than forming an alpha helix. Additionally, the hydrogen bonding interactions that stabilize the alpha helix may be disrupted due to the less favorable pH environment. Therefore, the difference in pH between pH 11.6 and pH 7.4 leads to differences in the protonation state of lysine residues and the overall electrostatic and hydrogen bonding interactions within the polypeptide chain, resulting in the formation of an alpha helix at pH 11.6 but not at pH 7.4." If you want, you can make an account and try submitted the same question to an Al bot (optional). Al bots are always being updated, they access previous text in your conversation, and are sensitive to differences in text formatting, but you will probably get a somewhat similar response. The response above that the Al gave me contains several errors. These errors include incorrect facts and incorrect implications about protein structure and amino acids. Analyze the response the Al gave me and identify 5 different errors that the Al made. For each sentence that you identify that contains an error you should: Clearly explain the biochemical nature of all the errors in the sentence. Note that there may be more than one error in a sentence. You should make sure to also explain how the errors could be corrected. Note that some of the errors in the answer are implied and not directly stated. So you should think about the 2280 course content carefully when composing your answer. When answering: for each error that you identify copy and paste the sentence of the Al response as a quote into your answer. Then below the Al error you have identified give your answer. You should not identify any simple spelling/terminology errors when answering.
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