The following alcohol can be synthesized two different ways utilizing a Grignard reaction. Using retrosynthetic analysis, draw the structures required for each pathway, assuming the reaction will be quenched with an aqueous workup. HO CH3

The following alcohol can be synthesized two different ways utilizing a Grignard reaction. Using retrosynthetic analysis, draw the structures required for each pathway, assuming the reaction will be quenched with an aqueous workup. HO CH3

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter17: Alcohols And Phenols

Section17.SE: Something Extra

Problem 71AP: A problem often encountered in the oxidation of primary alcohols to acids is that esters are...

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Concept explainers

Aromatic Compounds

Aromatic organic compound or aromatic system is an important class of hydrocarbons under the branch of organic chemistry. Aromatic compounds are also called arenas. The definition of aromatic organic compounds can be stated as a class of organic compounds with a planar cyclic ring of atoms bonded through alternated single and double bonds. Due to these alternating bonds, a peculiar feature termed as ‘resonance’, that is, delocalization of pi electrons or the electrons is shared within the atoms of the ring which are present in the aromatic compounds. The word ‘aromatic’ includes a Greek word ‘aroma’ which means smell, indicating that they were named as such due to the sweet odor they produce. Many well-known flavors such as vanilla, cinnamon, and few scents from flowers are extracted from aromatic compounds. Benzene with chemical formula C6H6 is a very common aromatic compound that contains six atoms of carbon held in the cyclic ring of alternate double bonds. It is also to be noted that not all aromatic compounds contain benzene ring. This can be explained by Huckel’s rule.

Question

Can you help me draw both the intramolecular and intermolecular Gringnard reactions?

The following alcohol can be synthesized two different ways utilizing a Grignard reaction. Using retrosynthetic analysis, draw the structures required
for each pathway, assuming the reaction will be quenched with an aqueous workup.
HO
CH₁₂

For this part, draw the structure for the intramolecular pathway.
This question has two parts. Be sure to complete both parts before submitting your answer.
See the Hint for how to draw the Grignard reagent so that the system will grade your answer correctly.

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