The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2? 2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.
The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2? 2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Follow these directions to access the entries for PTGS1 and PTGS2 in the “Gene” database at the
NCBI Website:A. First, go to the NCBI homepage using the link on the lab webpage, or by going to:
http://www.ncbi.nlm.nih.gov
- Select “Gene” from the database pulldown menu. Type “PTGS” in the search box, then
click “Go.”
- Scan the results for the “Homo sapiens” entries. There should be one called “PTGS1” and
one called “PTGS2.”
- Select each entry by clicking on its name, then read the paragraph under the “Summary”
section for each entry.
- The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit
both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to
discover a selective inhibitor to PTGS2?
2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers
design a drug that binds to PTGS1, but not to PTGS2.
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