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The disease cystic fibrosis is the result of a mutation in the gene that encodes the cystic fibrosis transmembrane regulator (CFTR), a channel protein that allows chloride to exit the cell. A partial sequence of the CFTR gene is shown below, with the correct reading frame indicated. The most serious form of the disease results from the deletion of three consecutive nucleotides, as shown. 504 505 506 507 508 509 510 511 512 normal gene sequence GAA AAT ATC ATC TTT GGT GTT TCC TAT...

The disease cystic fibrosis is the result of a mutation in the gene that encodes the cystic fibrosis transmembrane regulator (CFTR), a channel protein that allows chloride to exit the cell. A partial sequence of the CFTR gene is shown below, with the correct reading frame indicated. The most serious form of the disease results from the deletion of three consecutive nucleotides, as shown. 504 505 506 507 508 509 510 511 512 normal gene sequence GAA AAT ATC ATC TTT GGT GTT TCC TAT...

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The disease cystic fibrosis is the result of a mutation in the gene that encodes the cystic fibrosis transmembrane regulator (CFTR), a channel protein that allows chloride to exit the cell. A partial sequence of the CFTR gene is shown below, with the correct reading frame indicated. The most serious form of the disease results from the deletion of three consecutive nucleotides, as shown. 504 505 506 507 508 509 510 511 512 normal gene sequence GAA AAT ATC ATC TTT GGT GTT TCC TAT... mutated gene sequence GAA AAT ATC AT---T GGT GTT TCC TAT... What is the amino acid sequence for the normal protein? *** What is the amino acid sequence for the mutated protein?
Transcribed Image Text:The disease cystic fibrosis is the result of a mutation in the gene that encodes the cystic fibrosis transmembrane regulator (CFTR), a channel protein that allows chloride to exit the cell. A partial sequence of the CFTR gene is shown below, with the correct reading frame indicated. The most serious form of the disease results from the deletion of three consecutive nucleotides, as shown. 504 505 506 507 508 509 510 511 512 normal gene sequence GAA AAT ATC ATC TTT GGT GTT TCC TAT... mutated gene sequence GAA AAT ATC AT---T GGT GTT TCC TAT... What is the amino acid sequence for the normal protein? *** What is the amino acid sequence for the mutated protein?
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