The common amino acids are polyprotic acids. All amino acids contain an amino group and a carboxyl group. Some amino acids contain ionizable side chains. The presence of an ionizable side chain creates a third ionizable group. For a diprotic amino acid such as glycine (structure shown below), three forms are possible. These forms, the fully protonated (AA*), single deprotonated (AA°), and completely deprotonated (AA') exhibit different acid-base properties. HO, NH,+ NH,+ NH, HA (AA+) Neutral A- (AAº) (AA:) The Ka describing the AA+ and the AA° equilibrium is 4.57 x10-3, while the Ka involving AA° and the anionic form AA- is a much smaller 2.51 x 10-10. The neutral form, AA° is referred to as isoelectric glycine. All amino acids can assume the isoelectric form under proper conditions. Calculate the pH of a 0.1 M solution prepared from the salt glycine hydrochloride (hint: use ICE table). а.
The common amino acids are polyprotic acids. All amino acids contain an amino group and a carboxyl group. Some amino acids contain ionizable side chains. The presence of an ionizable side chain creates a third ionizable group. For a diprotic amino acid such as glycine (structure shown below), three forms are possible. These forms, the fully protonated (AA*), single deprotonated (AA°), and completely deprotonated (AA') exhibit different acid-base properties. HO, NH,+ NH,+ NH, HA (AA+) Neutral A- (AAº) (AA:) The Ka describing the AA+ and the AA° equilibrium is 4.57 x10-3, while the Ka involving AA° and the anionic form AA- is a much smaller 2.51 x 10-10. The neutral form, AA° is referred to as isoelectric glycine. All amino acids can assume the isoelectric form under proper conditions. Calculate the pH of a 0.1 M solution prepared from the salt glycine hydrochloride (hint: use ICE table). а.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:The common amino acids are polyprotic acids. All amino acids contain an amino group and a carboxyl
group. Some amino acids contain ionizable side chains. The presence of an ionizable side chain creates a
third ionizable group. For a diprotic amino acid such as glycine (structure shown below), three forms are
possible. These forms, the fully protonated (AA*), single deprotonated (AA°), and completely
deprotonated (AA) exhibit different acid-base properties.
NH;+
NH,+
NH,
Neutral
H,A
(AA+)
A-
(AA•)
(AA-)
The Ka describing the AA* and the AA° equilibrium is 4.57 x10-3, while the Ka involving AA° and the
anionic form AA- is a much smaller 2.51 x 10-10, The neutral form, AA° is referred to as isoelectric glycine.
All amino acids can assume the isoelectric form under proper conditions.
a. Calculate the pH of a 0.1 M solution prepared from the salt glycine hydrochloride (hint: use ICE
table).
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