The amino acid arginine ionizes according to the following scheme: NH, NH2 NH2 H NH, C=N C=N C=N C=N-H pk = 2.17 -H pK. = 8.99 -H pK = 125 -H* H. NH NH NH NH H (CH,)a H (CH), +H* (CH)a (CH,)a H,N-C-coo- +H* +H* H-N*-C-COOH H-N-C-Co- H,N-C-co- H. нн H. H II II IV (a) Calculate the isoelectric point of arginine. You can neglect contributions from form I. Why? (b) Calculate the average charge on arginine when pH = 9.20. (Hìnt: Find the average charge for each ionizable group and sum these together.) (c) Is the value of average charge you calculated in part b reasonable, given the pl you calculated in part a? Explain your answer.
The amino acid arginine ionizes according to the following scheme: NH, NH2 NH2 H NH, C=N C=N C=N C=N-H pk = 2.17 -H pK. = 8.99 -H pK = 125 -H* H. NH NH NH NH H (CH,)a H (CH), +H* (CH)a (CH,)a H,N-C-coo- +H* +H* H-N*-C-COOH H-N-C-Co- H,N-C-co- H. нн H. H II II IV (a) Calculate the isoelectric point of arginine. You can neglect contributions from form I. Why? (b) Calculate the average charge on arginine when pH = 9.20. (Hìnt: Find the average charge for each ionizable group and sum these together.) (c) Is the value of average charge you calculated in part b reasonable, given the pl you calculated in part a? Explain your answer.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Transcribed Image Text:The amino acid arginine ionizes according to the following scheme:
NH,
NH2
NH2
H
NH,
C=N
C=N
C=N
C=N-H
pk = 2.17
-H
pK. = 8.99
-H
pK = 125
-H*
H.
NH
NH
NH
NH
H (CH,)a
H (CH),
+H*
(CH)a
(CH,)a
H,N-C-coo-
+H*
+H*
H-N*-C-COOH
H-N-C-Co-
H,N-C-co-
H.
нн
H.
H
II
II
IV
(a) Calculate the isoelectric point of arginine. You can neglect contributions
from form I. Why?
(b) Calculate the average charge on arginine when pH = 9.20. (Hìnt: Find
the average charge for each ionizable group and sum these together.)
(c) Is the value of average charge you calculated in part b reasonable, given
the pl you calculated in part a? Explain your answer.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON