T/F: Based on the information above, vorinostat treatment leads to the increased expression of p21. True Qu False T/F: P21 is most likely a tumor suppressor.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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In addition to mutations, changes in chromatin structure as a result of histone acetylation/deacetylation or DNA methylation
are commonly associated with cancer. Vorinostat is an FDA-approved drug that is useful against a variety of cancers,
including cutaneous T-cell lymphoma (CTCL). It acts as a histone deacetylase (HDAC) inhibitor, leading to increased
acetylation at the promoter of certain genes, including p21.
T/F: Based on the information above, vorinostat treatment leads to the increased expression of p21.
O True
O False
Qu
T/F: P21 is most likely a tumor suppressor.
O True
O False
Transcribed Image Text:In addition to mutations, changes in chromatin structure as a result of histone acetylation/deacetylation or DNA methylation are commonly associated with cancer. Vorinostat is an FDA-approved drug that is useful against a variety of cancers, including cutaneous T-cell lymphoma (CTCL). It acts as a histone deacetylase (HDAC) inhibitor, leading to increased acetylation at the promoter of certain genes, including p21. T/F: Based on the information above, vorinostat treatment leads to the increased expression of p21. O True O False Qu T/F: P21 is most likely a tumor suppressor. O True O False
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