Target compound: Main starting material: OH

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter20: Carboxylic Acids And Nitriles
Section20.SE: Something Extra
Problem 40AP: Thioglycolic acid, HSCH2CO2H, a substance used in depilatory agents (hair removers) has pKa = 3.42....
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Aside from the specified main starting material, only the following compounds can be used as sources of the carbon backbone for the target compound:

acetaldehyde

ethanol

propanoic acid

acetic acid

ethyl bromoacetate

propan-1-ol

benzene

(2E,4E)-hexa-2,4-diene

propan-2-ol

buta-1,3-diene

methanol

propan-2-one (acetone)

(chloromethyl)benzene (benzyl chloride)

5-methyloxolan-2-one

sodium cyanide

1-(chloromethyl)-4-methylbenzene

phenylacetaldehyde

sodium methoxide

diethyl propanedioate (diethyl malonate)

piperidine

sodium ethoxide

  • There are no restrictions with regards to the use of other reagents such as catalysts, solvents, redox agents, protection/deprotection agents, etc. as long as they will not be used as sources of carbon for the skeleton of the target compound.
  • Design a retrosynthetic map and from it, propose a multi-step synthetic approach for the preparation of the target compound from the specified starting material.
  • Write both the retrosynthesis and synthesis plan with brief explanation
Target compound:
Main starting material:
Transcribed Image Text:Target compound: Main starting material:
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