Table 1. DNA Sequence 1 from Lactose-Tolerant and -Intolerant Individuals Individual Phenotype Sequence 1 A IV-3 Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG *Sequence 1 is a nucleotide sequence corresponding to nucleotides 19923-13902 upstream from the start of the lactase gene. BIV-4 BIV-8 BIV-9 CIV-3 DIV-4 Table 2. DNA Sequence 2 from Lactose-Tolerant and -Intolerant Individuals Phenotype Individual A IV-3 Sequence 2* Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA *Sequence 2 is a nucleotide sequence corresponding to nucleotides 30192-30173 upstream of the start of the lactase gene. BIV-4 BIV-8 BIV-9 CIV-3 DIV-4 + PEDIGREES + INFO We have some sequences!! To detect any pattern, you need to find consistent associations between the people with lactose intolerance and mutations. STEP 1: Use the pedigrees to fill in each individual's phenotype (e.g., lactose tolerant or lactose intolerant) in the second column of the tables on the left (under "phenotype"). • STEP 2: Go by nucleotide position in each table. Circle all the different nucleotides between at least two sequences in each table. I suggest using different colors for each nucleotide for easier visualization. Your show-your-work should reflect that you completed these steps. When ready click "Next."
Table 1. DNA Sequence 1 from Lactose-Tolerant and -Intolerant Individuals Individual Phenotype Sequence 1 A IV-3 Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG *Sequence 1 is a nucleotide sequence corresponding to nucleotides 19923-13902 upstream from the start of the lactase gene. BIV-4 BIV-8 BIV-9 CIV-3 DIV-4 Table 2. DNA Sequence 2 from Lactose-Tolerant and -Intolerant Individuals Phenotype Individual A IV-3 Sequence 2* Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA *Sequence 2 is a nucleotide sequence corresponding to nucleotides 30192-30173 upstream of the start of the lactase gene. BIV-4 BIV-8 BIV-9 CIV-3 DIV-4 + PEDIGREES + INFO We have some sequences!! To detect any pattern, you need to find consistent associations between the people with lactose intolerance and mutations. STEP 1: Use the pedigrees to fill in each individual's phenotype (e.g., lactose tolerant or lactose intolerant) in the second column of the tables on the left (under "phenotype"). • STEP 2: Go by nucleotide position in each table. Circle all the different nucleotides between at least two sequences in each table. I suggest using different colors for each nucleotide for easier visualization. Your show-your-work should reflect that you completed these steps. When ready click "Next."
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Table 1. DNA Sequence 1 from Lactose-Tolerant and -Intolerant Individuals
Phenotype
Individual
A IV-3
Sequence 1*
Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGCCCCTGG
Copy 2, Chromosome 2: TAAGATAATGTAGCCCCTGG
*Sequence 1 is a nucleotide sequence corresponding to nucleotides 19923-13902 upstream from the start of the lactase gene.
BIV-4
BIV-8
BIV-9
CIV-3
DIV-4
Table 2. DNA Sequence 2 from Lactose-Tolerant and -Intolerant Individuals
Phenotype
Individual
A IV-3
Sequence 2*
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA
Copy 1, Chromosome 2: ATAAAGGACGCTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACGCTCTTGACAA
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
Copy 2, Chromosome 2: ATAAAGGACACTCTTGACAA
*Sequence 2 is a nucleotide sequence corresponding to nucleotides 30192-30173 upstream of the start of the lactase gene.
BIV-4
BIV-8
BIV-9
view.genial.ly
CIV-3
DIV-4
Want to make creations as awesome as this one?
+ PEDIGREES
+ INFO
We have some sequences!!
To detect any pattern, you need to find consistent
associations between the people with lactose
intolerance and mutations.
G
STEP 1: Use the pedigrees to fill in each
individual's phenotype (e.g., lactose tolerant or
lactose intolerant) in the second column of the
tables on the left (under "phenotype").
• STEP 2: Go by nucleotide position in each table.
Circle all the different nucleotides between at least
two sequences in each table.
REGISTER NOW
I suggest using different colors for each nucleotide
for easier visualization.
Your show-your-work should reflect that you
completed these steps.
When ready click "Next."
+
Transcribed Image Text:Copy 2, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 1, Chromosome 2: TAAGATAATGTAGTCCCTGG
Copy 2. Chromosome 2: TAAGATAATGTAGCCCCTGG
11
III
I
11
III
IV
V
42
Family A
11
Family C
Lactose tolerant female
O Lactose intolerant female
I
Copy 1, Chromosome 2: ATAAAGGACACTCTTGACAA
||
IV
V
11
III
IV
V
Lactose tolerant male
Lactose intolerant male
We have some sequen
? Unknown phenotype
Deceased
12 13 14
Pedigrees of Families A, B, C, and D. (Modified from HHMI Biointeractive. Adapted from a figure in Enattah, N. S., et al. 2002 Nature Genetics 30: 233-237.)
Family B
Family D
Your show-your-work sho
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