Synthesis of the activated form of acetate (acetyl-CoA) is carried out in an ATP-dependent process. Acetate+ CoA + ATP → Acetyl-CoA + AMP + PP₁ The AG' for the hydrolysis of acetyl-CoA to acetate and CoA is -32.2 kJ/mol, and that for hydrolysis of ATP to AMP and PP; is -30.5 kJ/mol. Calculate AG" for the ATP-dependent synthesis of acetyl-CoA shown in the equation. AG" = Almost all cells contain the enzyme inorganic pyrophosphatase, which catalyzes the hydrolysis of PP; to P₁. What effect does the presence of this enzyme have on the synthesis of acetyl-CoA? Hydrolysis of pyrophosphate decreases the rate of the reaction. Hydrolysis of pyrophosphate has no effect on the reaction. Hydrolysis of pyrophosphate increases the rate of the reaction. Hydrolysis of pyrophosphate shifts the equilibrium of the reaction to the right, making the formation of acetyl-CoA energetically more favorable. Hydrolysis of pyrophosphate shifts the equilibrium of the reaction to the left, making the formation of acetyl-CoA energetically less favorable. kJ mol

Synthesis of the activated form of acetate (acetyl-CoA) is carried out in an ATP-dependent process. Acetate+ CoA + ATP → Acetyl-CoA + AMP + PP₁ The AG' for the hydrolysis of acetyl-CoA to acetate and CoA is -32.2 kJ/mol, and that for hydrolysis of ATP to AMP and PP; is -30.5 kJ/mol. Calculate AG" for the ATP-dependent synthesis of acetyl-CoA shown in the equation. AG" = Almost all cells contain the enzyme inorganic pyrophosphatase, which catalyzes the hydrolysis of PP; to P₁. What effect does the presence of this enzyme have on the synthesis of acetyl-CoA? Hydrolysis of pyrophosphate decreases the rate of the reaction. Hydrolysis of pyrophosphate has no effect on the reaction. Hydrolysis of pyrophosphate increases the rate of the reaction. Hydrolysis of pyrophosphate shifts the equilibrium of the reaction to the right, making the formation of acetyl-CoA energetically more favorable. Hydrolysis of pyrophosphate shifts the equilibrium of the reaction to the left, making the formation of acetyl-CoA energetically less favorable. kJ mol

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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