Suppose that the incidence rate pf myocardial infraction (MI) was 5 per 100 among 45 - 50 year old men in 2000. To look at changes in incidence over time, 5000 men in this age groups were followed for 1 year starting in 2010. Twenty new cases of MI were found. Suppose we eventually plan to accumulate 50 MI cases during the period 2010-2015. Suppose that 20% of the patients with MI in 2000 died within 24 hours. This proportion is called the 24 hour case fatality rate. A test is performed to see if the true proportion of 24 hour case fatality rate differs from 20%, with significance level of 0.01. Assume that the 24-hour case fatality rate is truly 25% during the period. how large a sample is needed to achieve 92% power?

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