Succinylcholine is a fast-acting, short-duration muscle relaxant. Doctors use the chemical before inserting a tube into a patient's trachea. Immediately after administering succinylcholine, the patient experiences muscle paralysis and needs a respirator for the rest of the examination. Succinylcholine causes paralysis by competitively inhibiting acetylcholinesterase, a nervous system enzyme. However, serum cholinesterase hydrolyzes succinylcholine. Paralysis lasts for several minutes until serum cholinesterase hydrolyzes all the succinylcholine. As a safety measure, doctors measure serum cholinesterase activity before examinations that require succinylcholine. These measurements help the doctor determine the appropriate succinylcholine dosage. Normal serum cholinesterase has a KM of 1.4 mM and exhibits 80 units of activity per liter. Assume the typical succinylcholine dose is well below the concentration required to induce serum cholinesterase's maximal reaction velocity, Vmax. What would happen to a patient with a mutated serum cholinesterase that has a KM of 10 mM, but an unchanged Vmax ? Paralysis will last a longer amount of time. Paralysis will last the same amount of time. Paralysis will last a shorter amount of time. What would happen to a patient with a mutated serum cholinesterase that has 10 units of activity per liter? Paralysis will last the same amount of time. Paralysis will last a shorter amount of time. Paralysis will last a longer amount of time.
Succinylcholine is a fast-acting, short-duration muscle relaxant. Doctors use the chemical before inserting a tube into a patient's trachea. Immediately after administering succinylcholine, the patient experiences muscle paralysis and needs a respirator for the rest of the examination. Succinylcholine causes paralysis by competitively inhibiting acetylcholinesterase, a nervous system enzyme. However, serum cholinesterase hydrolyzes succinylcholine. Paralysis lasts for several minutes until serum cholinesterase hydrolyzes all the succinylcholine. As a safety measure, doctors measure serum cholinesterase activity before examinations that require succinylcholine. These measurements help the doctor determine the appropriate succinylcholine dosage. Normal serum cholinesterase has a KM of 1.4 mM and exhibits 80 units of activity per liter. Assume the typical succinylcholine dose is well below the concentration required to induce serum cholinesterase's maximal reaction velocity, Vmax. What would happen to a patient with a mutated serum cholinesterase that has a KM of 10 mM, but an unchanged Vmax ? Paralysis will last a longer amount of time. Paralysis will last the same amount of time. Paralysis will last a shorter amount of time. What would happen to a patient with a mutated serum cholinesterase that has 10 units of activity per liter? Paralysis will last the same amount of time. Paralysis will last a shorter amount of time. Paralysis will last a longer amount of time.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Transcribed Image Text:Succinylcholine is a fast-acting, short-duration muscle relaxant. Doctors use the chemical before inserting a tube into a patient's
trachea. Immediately after administering succinylcholine, the patient experiences muscle paralysis and needs a respirator for the
rest of the examination.
Succinylcholine causes paralysis by competitively inhibiting acetylcholinesterase, a nervous system enzyme. However, serum
cholinesterase hydrolyzes succinylcholine. Paralysis lasts for several minutes until serum cholinesterase hydrolyzes all
the succinylcholine.
As a safety measure, doctors measure serum cholinesterase activity before examinations that require succinylcholine. These
measurements help the doctor determine the appropriate succinylcholine dosage. Normal serum cholinesterase has a Kỵ of
1.4 mM and exhibits 80 units of activity per liter. Assume the typical succinylcholine dose is well below the concentration
required to induce serum cholinesterase's maximal reaction velocity, Vmax.
What would happen to a patient with a mutated serum
cholinesterase that has a Kỵ of 10 mM, but an
unchanged Vmax ?
Paralysis will last a longer amount of time.
Paralysis will last the same amount of time.
Paralysis will last a shorter amount of time.
What would happen to a patient with a mutated serum
cholinesterase that has 10 units of activity per liter?
Paralysis will last the same amount of time.
Paralysis will last a shorter amount of time.
Paralysis will last a longer amount of time.
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