3. (Kaplan-Meier and Nelson-Aalen estimators) Consider the following censored lifetime data: 12 23 13 23+ 25 14+ 15+ 16+ 18 25 26 26 ktk 1 2 3 4 Recall that the + sign corresponds to censoring: for e.g., 14+ means exit by censoring at age 14. (a) Find estimates of mortality rate (t), cumulative mortality rate A(t), and the survival probability (Nelson-Aalen and Kaplan-Meier) S (t). Provide your answers in 4 decimal digits. d 18 19 21 22+ 26+ 27+ 29 30 Yk λx Ak SKM SNA where to denotes event times, d, the number of exit by the event at t, y the num- ber of individuals at risk at t,= (t), A = A(t), while SKM and SNA are respectively Kaplan-Meier and Nelson-Aalen estimates of S (tk). Please complete the table in your assignment submission. (b) Use R to plot estimated cumulative hazard rate Ã(t) and survival probability S(t). (c) It is known that the estimated variance Var(SNA (1)) of the estimate SNA(t) of survival probability S(t) for the Nelson-Aalen estimator is given by Var(SNA (1)) = [SNA (1)]² Σ de (yx — de) kast Use the formula to estimate the variance of S (t) at age t = 18. (d) Derive a 95% confidence interval for S(t) aged t = 18 using SNA (1). JL 1

MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
Problem 1P
Question

Please do 3c and 3d with handwritten working out 

3. (Kaplan-Meier and Nelson-Aalen estimators)
Consider the following censored lifetime data:
12
23
13
23+ 25
14+ 15+ 16+ 18
25
26
26
ktk
1
2
3
4
Recall that the + sign corresponds to censoring: for e.g., 14+ means exit by censoring at
age 14.
(a) Find estimates of mortality rate (t), cumulative mortality rate A(t), and the survival
probability (Nelson-Aalen and Kaplan-Meier) S (t).
Provide your answers in 4 decimal digits.
d
18
19
21
22+
26+ 27+ 29 30
Yk
λx
Ak
SKM
SNA
where to denotes event times, d, the number of exit by the event at t, y the num-
ber of individuals at risk at t,= (t), A = A(t), while SKM and SNA are
respectively Kaplan-Meier and Nelson-Aalen estimates of S (tk).
Please complete the table in your assignment submission.
(b) Use R to plot estimated cumulative hazard rate Ã(t) and survival probability S(t).
(c) It is known that the estimated variance Var(SNA (1)) of the estimate SNA(t) of survival
probability S(t) for the Nelson-Aalen estimator is given by
Var(SNA (1)) = [SNA (1)]² Σ de (yx — de)
kast
Use the formula to estimate the variance of S (t) at age t = 18.
(d) Derive a 95% confidence interval for S(t) aged t = 18 using SNA (1).
JL
1
Transcribed Image Text:3. (Kaplan-Meier and Nelson-Aalen estimators) Consider the following censored lifetime data: 12 23 13 23+ 25 14+ 15+ 16+ 18 25 26 26 ktk 1 2 3 4 Recall that the + sign corresponds to censoring: for e.g., 14+ means exit by censoring at age 14. (a) Find estimates of mortality rate (t), cumulative mortality rate A(t), and the survival probability (Nelson-Aalen and Kaplan-Meier) S (t). Provide your answers in 4 decimal digits. d 18 19 21 22+ 26+ 27+ 29 30 Yk λx Ak SKM SNA where to denotes event times, d, the number of exit by the event at t, y the num- ber of individuals at risk at t,= (t), A = A(t), while SKM and SNA are respectively Kaplan-Meier and Nelson-Aalen estimates of S (tk). Please complete the table in your assignment submission. (b) Use R to plot estimated cumulative hazard rate Ã(t) and survival probability S(t). (c) It is known that the estimated variance Var(SNA (1)) of the estimate SNA(t) of survival probability S(t) for the Nelson-Aalen estimator is given by Var(SNA (1)) = [SNA (1)]² Σ de (yx — de) kast Use the formula to estimate the variance of S (t) at age t = 18. (d) Derive a 95% confidence interval for S(t) aged t = 18 using SNA (1). JL 1
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