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Biochemistry
SKILL EXERCISES POST-ACTIVITY 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer.

SKILL EXERCISES POST-ACTIVITY 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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the wheel SKILL EXERCISES ntral axi 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). POST-ACTIVITY epresent presents d in the DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer. u have of the 2. Describe how water contributes to the favorable free energy change that makes protein folding a spontaneous process. Your instructor may assign one or more of these questions: 3. If a protein were placed in a nonpolar solvent, would it have the same structure as the same protein placed in water? Justify your answer. hines 4. Compare and contrast the entropy changes of the dissolution of the following two amino acids phenylalanine and aspartate (in water). e and 5. The graph below shows energy information with thermodynamic parameters involved in a macromolecular interaction. Propose a type of interaction that matches these data. 60 ess in 40 20 -20 -40 TAS AG ΔΗ Contributed by Rodney Austin Martina Ederer Tracey Murray and Heather Tenson Energy (jow/r)
Transcribed Image Text:the wheel SKILL EXERCISES ntral axi 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). POST-ACTIVITY epresent presents d in the DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer. u have of the 2. Describe how water contributes to the favorable free energy change that makes protein folding a spontaneous process. Your instructor may assign one or more of these questions: 3. If a protein were placed in a nonpolar solvent, would it have the same structure as the same protein placed in water? Justify your answer. hines 4. Compare and contrast the entropy changes of the dissolution of the following two amino acids phenylalanine and aspartate (in water). e and 5. The graph below shows energy information with thermodynamic parameters involved in a macromolecular interaction. Propose a type of interaction that matches these data. 60 ess in 40 20 -20 -40 TAS AG ΔΗ Contributed by Rodney Austin Martina Ederer Tracey Murray and Heather Tenson Energy (jow/r)
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