SIS. echanism for the first step. For each of the subsequent intermediates, design a short sequence ccomplish the desired transformation. Pay close attention to stereochemistry. OTIPS OTIPS RO₂C part Grubbs' catalyst steps?

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
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Question 2,

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Problem 2. The following clever sequence of transformations was reported as part of a total synthesis.
Provide a mechanism for the first step. For each of the subsequent intermediates, design a short sequence
of steps to accomplish the desired transformation. Pay close attention to stereochemistry.
OTIPS
OTIPS
Me
Grubbs' catalyst
RO₂C
OTIPS
H
H
that sud
H
steps?
H
Me
steps?
Transcribed Image Text:Problem 2. The following clever sequence of transformations was reported as part of a total synthesis. Provide a mechanism for the first step. For each of the subsequent intermediates, design a short sequence of steps to accomplish the desired transformation. Pay close attention to stereochemistry. OTIPS OTIPS Me Grubbs' catalyst RO₂C OTIPS H H that sud H steps? H Me steps?
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