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Side effects might also be reduced or eliminated by varying apparently harmless substituents. For example, the halogen substituents of the antifungal agent UK 47265 were varied i order to find a compound that was less toxic to the liver. This led to the successful antifungal agent fluconazole. N. N. OH N' OH N UK 47265 Fluconazole

Side effects might also be reduced or eliminated by varying apparently harmless substituents. For example, the halogen substituents of the antifungal agent UK 47265 were varied i order to find a compound that was less toxic to the liver. This led to the successful antifungal agent fluconazole. N. N. OH N' OH N UK 47265 Fluconazole

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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In the two compounds below::

what the difference between cl and F in toxicity?

why replacing the cl with F render the compound less toxic? ( they both electron withdrawing group)

Side effects might also be reduced or eliminated by varying apparently harmless substituents. For example, the halogen substituents of the antifungal agent UK 47265 were varied in order to find a compound that was less toxic to the liver. This led to the successful antifungal agent fluconazole. OH OH .CI UK 47265 Fluconazole * 46
Transcribed Image Text:Side effects might also be reduced or eliminated by varying apparently harmless substituents. For example, the halogen substituents of the antifungal agent UK 47265 were varied in order to find a compound that was less toxic to the liver. This led to the successful antifungal agent fluconazole. OH OH .CI UK 47265 Fluconazole * 46
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