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Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin, hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia. Normal genotype DNA mRNA CUGACU CCUGAGGAG Glutamic Glutamic Amino acid sequence acid DNA mRNA Amino acid sequence GG Leucine Threonine Proline Sickle cell anemia genotype GACU Normal UG G G Leucine Threonine Proline Valine Mutant Glutamic acid Normal red blood cells Sickled red blood cells Look at the model below. DNA Normal ---- Gene Sickle Gene -H-I-C Drag and drop the comect label into each box to construct an explanation about how sickle cells form function Amino Acid valine -Glutamic Acid People with sickle cell anemia inherit a specific mutated gene. A gene is a specific sequence on a piece of instead of Because of this change, the protein created has a different structure -Ovaline DNA glutamic acid In sickle cell anemia, the affected gene includes This decreases the ability of the red blood cell to

Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin, hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia. Normal genotype DNA mRNA CUGACU CCUGAGGAG Glutamic Glutamic Amino acid sequence acid DNA mRNA Amino acid sequence GG Leucine Threonine Proline Sickle cell anemia genotype GACU Normal UG G G Leucine Threonine Proline Valine Mutant Glutamic acid Normal red blood cells Sickled red blood cells Look at the model below. DNA Normal ---- Gene Sickle Gene -H-I-C Drag and drop the comect label into each box to construct an explanation about how sickle cells form function Amino Acid valine -Glutamic Acid People with sickle cell anemia inherit a specific mutated gene. A gene is a specific sequence on a piece of instead of Because of this change, the protein created has a different structure -Ovaline DNA glutamic acid In sickle cell anemia, the affected gene includes This decreases the ability of the red blood cell to

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 24 ◄► Pause Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin; hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia. Amino acid sequence Q Zoom Normal genotype DNA GAC TGA GGA CTC mRNA CLUIG ACU CCUGAGGAG Glutamic acid Normal Leucine Threonine Proline mRNA CUG| ACU CCUGUG Amino acid sequence CTC Sickle cell anemia genotype DNA GAC TGA GGA CAC CTC Leucine Threonine Proline Valine Mutant Glutamic acid GAG Glutamic acid Normal red blood cells Culor Docil Sickled red blood cells Look at the model below. DNA 1-1-1-0² Normal Gene Sickle Gene |-H-I-² Drag and drop the correct label into each box to construct an explanation about how sickle cells form. function valine Amino Acid People with sickle cell anemia inherit a specific mutated gene. A gene is a specific sequence on a piece of instead of Because of this change, the protein created has a different structure . OGlutamic Acid DNA OValine glutamic acid Q Review /✔ Finish Test In sickle cell anemia, the affected gene includes This decreases the ability of the red blood cell to
Transcribed Image Text:Question 24 ◄► Pause Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin; hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia. Amino acid sequence Q Zoom Normal genotype DNA GAC TGA GGA CTC mRNA CLUIG ACU CCUGAGGAG Glutamic acid Normal Leucine Threonine Proline mRNA CUG| ACU CCUGUG Amino acid sequence CTC Sickle cell anemia genotype DNA GAC TGA GGA CAC CTC Leucine Threonine Proline Valine Mutant Glutamic acid GAG Glutamic acid Normal red blood cells Culor Docil Sickled red blood cells Look at the model below. DNA 1-1-1-0² Normal Gene Sickle Gene |-H-I-² Drag and drop the correct label into each box to construct an explanation about how sickle cells form. function valine Amino Acid People with sickle cell anemia inherit a specific mutated gene. A gene is a specific sequence on a piece of instead of Because of this change, the protein created has a different structure . OGlutamic Acid DNA OValine glutamic acid Q Review /✔ Finish Test In sickle cell anemia, the affected gene includes This decreases the ability of the red blood cell to
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