Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin: hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin: hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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
Transcribed Image Text:Sickle Cell Anemia
Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle
cell mutation affects the structure of hemoglobin; hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive
allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia.
Normal genotype
DNA GAC TGA GGA CTC
mRNA CU|G| ACU CCUGAG GAG
Amino acid
sequence
Glutamic
acid
Leucine Threonine Proline
mRNA|C|U|G
Amino acid
sequence
Sickle cell anemia genotype
DNA GAC TGA GGA CAC CTC
Glutamic
acid
Normal
CTC
Leucine Threonine Proline
ACU CCU GUG GAG
Glutamic
acid
Valine
Mutant
Normal red blood cells
35
nocul
Sickled red blood cells
Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
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