Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism. Use the image to answer the question. Which conclusion can you draw based on the diagram? A. The mutation changed the amino acid sequence during the translation step. B. A mutation caused the information in DNA to change during the transcription step. C. A change in the DNA sequence can be carried over to the translation and transcription steps. D. The change that affected the translation and transcription steps does not affect the organism.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism.
Use the image to answer the question.
Which conclusion can you draw based on the diagram?
-
A.
The mutation changed the amino acid sequence during the translation step.
-
B.
A mutation caused the information in DNA to change during the transcription step.
-
C.
A change in the DNA sequence can be carried over to the translation and transcription steps.
-
D.
The change that affected the translation and transcription steps does not affect the organism.
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Sickle-cell B-globin
Wild-type B-globin DNA
CTC
GAG
Mutant B-globin DNA
5'
13'
3'
31
CAC
15'
5
GTG
13'
MRNA
5'1
MRNA
5'
GAG
13'
GUG
13'
Normal hemoglobin
Sickle-cell hemoglobin
Val
Glu
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