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Sensipar is a pharmaceutical used for the treatment of hyperparathyroidism in patients with chronic kidney disease. Draw the enantiomer of the molecule shown below. Use a dash or wedge bond to indicate stereochemistry of substituents on asymmetric centers, where applicable. H

Sensipar is a pharmaceutical used for the treatment of hyperparathyroidism in patients with chronic kidney disease. Draw the enantiomer of the molecule shown below. Use a dash or wedge bond to indicate stereochemistry of substituents on asymmetric centers, where applicable. H

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Transcription for Educational Website** --- **Title: Understanding Stereochemistry in Pharmaceuticals: A Look at Sensipar** **Introduction:** This exercise focuses on the pharmaceutical compound Sensipar, which is used for treating hyperparathyroidism in patients with chronic kidney disease. The task is to draw the enantiomer of the given molecular structure, utilizing a dash or wedge bond to accurately convey the stereochemistry of substituents on asymmetric centers. **Molecular Structure:** The molecular structure provided in the exercise includes a complex arrangement with aromatic rings and specific stereochemical indicators, such as: - Aromatic benzene rings (depicted as hexagons). - A central carbon chain with substituents, including hydrogen (H) and fluorine (F), marked with solid and dashed wedges to show their spatial orientation. **Instructions:** Students are instructed to: 1. Draw the enantiomer of the given molecule. 2. Use a dashed or wedged bond to highlight the stereochemistry where necessary. **Tools:** A molecular drawing interface is provided, featuring a hexagonal grid workspace. It allows for the placement and manipulation of atoms, bonds, and rings. Users can select from a palette that includes various bond types, atom representations, and stereochemistry indicators. - **Atoms, Bonds, and Rings Menu:** This section contains tools to create standard and stereochemical bonds, insert aromatic rings, and modify atomic structures. - **Editing Tools:** Options to undo, redo, or reset the drawing, ensuring precise molecular depictions. **Conclusion:** Understanding how to accurately draw molecular enantiomers is crucial in the study of stereochemistry and drug efficacy. This exercise helps reinforce knowledge of how molecular orientation affects pharmaceutical activity, providing a hands-on learning experience. --- **Note for Educators:** Encourage students to explore the stereochemistry tools provided and discuss how altering molecular orientation can impact the biological activity of pharmaceuticals like Sensipar.
Transcribed Image Text:**Transcription for Educational Website** --- **Title: Understanding Stereochemistry in Pharmaceuticals: A Look at Sensipar** **Introduction:** This exercise focuses on the pharmaceutical compound Sensipar, which is used for treating hyperparathyroidism in patients with chronic kidney disease. The task is to draw the enantiomer of the given molecular structure, utilizing a dash or wedge bond to accurately convey the stereochemistry of substituents on asymmetric centers. **Molecular Structure:** The molecular structure provided in the exercise includes a complex arrangement with aromatic rings and specific stereochemical indicators, such as: - Aromatic benzene rings (depicted as hexagons). - A central carbon chain with substituents, including hydrogen (H) and fluorine (F), marked with solid and dashed wedges to show their spatial orientation. **Instructions:** Students are instructed to: 1. Draw the enantiomer of the given molecule. 2. Use a dashed or wedged bond to highlight the stereochemistry where necessary. **Tools:** A molecular drawing interface is provided, featuring a hexagonal grid workspace. It allows for the placement and manipulation of atoms, bonds, and rings. Users can select from a palette that includes various bond types, atom representations, and stereochemistry indicators. - **Atoms, Bonds, and Rings Menu:** This section contains tools to create standard and stereochemical bonds, insert aromatic rings, and modify atomic structures. - **Editing Tools:** Options to undo, redo, or reset the drawing, ensuring precise molecular depictions. **Conclusion:** Understanding how to accurately draw molecular enantiomers is crucial in the study of stereochemistry and drug efficacy. This exercise helps reinforce knowledge of how molecular orientation affects pharmaceutical activity, providing a hands-on learning experience. --- **Note for Educators:** Encourage students to explore the stereochemistry tools provided and discuss how altering molecular orientation can impact the biological activity of pharmaceuticals like Sensipar.
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