5. "Time-release" drugs work by releasing a drug to the body at aconstant rate such that the drug concentration at one time is notlarge enough as to cause harmful side effects OR not low enoughto the point where it is an ineffective therapeutic. A designElastic impermeable membraneSemipermeableSaturatedNacl solutionDrugmembraneschematic of a time-release pill is shown below. Explain how itworks from an osmotic pressure standpoint.Rigid wall containingtiny holes

concentration. It is opposite to the process of diffusion. In the given picture a drug is needed to…

Answered: schematic of a time-release pill is…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

5. "Time-release" drugs work by releasing a drug to the body at a
constant rate such that the drug concentration at one time is not
large enough as to cause harmful side effects OR not low enough
to the point where it is an ineffective therapeutic. A design
Elastic impermeable membrane
Semipermeable
Saturated
Nacl solution
Drug
membrane
schematic of a time-release pill is shown below. Explain how it
works from an osmotic pressure standpoint.
Rigid wall containing
tiny holes

Expert Solution

Step 1 Osmosis is a process in which a solvent molecule migrates from low concentration to high

concentration. It is opposite to the process of diffusion. In the given picture a drug is needed to be administered inside the semipermeable membrane. The administered drug can be both water-soluble or insoluble. It should possess high potency, short half-life, and good for chronic treatments.
NaCl is acting as an Osmogen which is favoring osmosis of water from low concentration to high concentration. In this way, the concentration of the drug will equalize both sides of the membrane by a generation of the concentration gradient and uniform flow of drug can occur well in hydrated formulations.
The semipermeable membrane should be stable, inert, rigid, selectively permeable, permeable to water, impermeable to solute so that effective flow of water can be attained by the generation of osmotic pressure.

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