Ribosome ER signal xaquence Ass pokpeptidea being muda SRP bindtan ER signial sequence nd caum traralation to paun. SRP binda to an SAP receptor in the ER membrane, which a located nast toa channel. Forthis binding to oce, proteira within SRP wnd the SRP recaptor mut abo be bound by GTP. Cytomal ER membran ER lumen Charnel SRP receptor The GTPbinding proteina wthin SRP nd the SRP recaptor hydralyre their CTP, Caing the relemn of SRP. The lowa trunalation to reauma, and the polypeptide i threded through channal nto the ER lumen FIGURE 17.6 Tarwting of paypeptites lo the endoplamt retkulum mentrae via SRP. Ineukaryoes, ve ral categories of proicins are fiest largeled to the IR membrane via SRP. These include ecreied proleins z well as proleins that are destined to stay in the ER, Golgi apparatus, lysosomes, or vacuoles.

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