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reduction in histone acetylation and reduced gene transcription. Given this information, which of the following could describe the normal functioning of CBP? A. CBP adds acetyl groups to the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed B. CBP removes acetyl groups from the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. C. CBP adds acetyl groups to the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. D.CBP removes acetyl groups from the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed.

reduction in histone acetylation and reduced gene transcription. Given this information, which of the following could describe the normal functioning of CBP? A. CBP adds acetyl groups to the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed B. CBP removes acetyl groups from the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. C. CBP adds acetyl groups to the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. D.CBP removes acetyl groups from the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Studies have shown that activity by a protein known as CREB-binding protein (CBP) results in increased amounts of gene transcription. Patients with a neurological condition known as Rubinstein-Taybi Syndrome, which causes mental retardation and skeletal abnormalities, have been shown to have a mutation in the gene that codes for this protein, resulting in reduction in histone acetylation and reduced gene transcription. Given this information, which of the following could describe the normal functioning of CBP? A. CBP adds acetyl groups to the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed B. CBP removes acetyl groups from the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. C. CBP adds acetyl groups to the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. D.CBP removes acetyl groups from the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed.
Transcribed Image Text:Studies have shown that activity by a protein known as CREB-binding protein (CBP) results in increased amounts of gene transcription. Patients with a neurological condition known as Rubinstein-Taybi Syndrome, which causes mental retardation and skeletal abnormalities, have been shown to have a mutation in the gene that codes for this protein, resulting in reduction in histone acetylation and reduced gene transcription. Given this information, which of the following could describe the normal functioning of CBP? A. CBP adds acetyl groups to the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed B. CBP removes acetyl groups from the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. C. CBP adds acetyl groups to the side chains of amino acids in histone tails, causing the chromatin to decondense and allowing access to previously hidden promoter regions. D.CBP removes acetyl groups from the sugar- phosphate backbone of the histone core DNA, causing the DNA to open up and become less condensed.
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