Redraw the peptide (without the requirement to show every atom) in its most common Consider the peptide amino terminus-glycine-valine-proline-carboxylic acid terminus A. formal charge. Indicate the hybridization of every non-hydrogen atom. B. C. 4. D. approximately what fraction of amino verminus is in its neutral protonation state at pH7? Carboxylic acid terminus? mat the pka of the amino terminus is 10 and of the carboxylic acid terminus at pH 7,roughly what fraction of the entire peptide is in the state shown in (A)? he peptide reacts with acetyl chloride to form one main organic product. Draw the reaction, showing the mechanism using the arrow formalism. What type of reaction is this (max 2 words)? E. F. H. At pH7, how does the net charge of your product from (F) compare to that of the initial peptide in (C)? G. Instead of reacting the peptide with acetyl chloride, you instead add an enzyme that facilitates methylation of the amino terminus with S-adenosylmethionine (SAM) as the methyl donor. Draw monomethylation of the amino terminus by SAM using the arrow formalism (feel free to abbreviate any parts of the peptide not directly involved in the reaction as "peptide"). 1.

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Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Draw the peptide, showing every atom, in the protonation state where every atom has zero
Consider the peptide amino terminus-glycine-valine-proline-carboxylic acid terminus
A.
formal charge.
B.
Indicate the hybridization of every non-hydrogen atom.
C.
protonation state at pH 7.
D.
pproximnately what fraction of amino terminus is in its neutral protonation state at pH7?
Carboxylic acid terminus?
AtPH 7, roughly what fraction of the entire peptide is in the state shown in (A)?
he peptide reacts with acetyl chloride to form one main organic product. Draw the reaction,
showing the mechanism using the arrow formalism.
What type of reaction is this (max 2 words)?
E.
F.
G.
* At pH , how does the net charge of your product from (F) compare to that of the initial peptide
in (C)?
Instead of reacting the peptide with acetyl chloride, you instead add an enzyme that facilitates
methylation of the amino terminus with S-adenosylmethionine (SAM) as the methyl donor.
Draw monomethylation of the amino terminus by SAM using the arrow formalism (feel free to
abbreviate any parts of the peptide not directly involved in the reaction as "peptide").
What type of reaction is this (max 2 words)?
Which of the following classifiers best describes the reactive carbon involved in this reaction:
methyl, primary, secondary, tertiary?
You allow the methylation with SAM to continue until the amino terminus is no longer
1.
J.
K.
L.
nucleophilic. Draw the final product.
1. At pH 7, what fraction of your final product is in the state where every atom has zero formal
charge?
Transcribed Image Text:Draw the peptide, showing every atom, in the protonation state where every atom has zero Consider the peptide amino terminus-glycine-valine-proline-carboxylic acid terminus A. formal charge. B. Indicate the hybridization of every non-hydrogen atom. C. protonation state at pH 7. D. pproximnately what fraction of amino terminus is in its neutral protonation state at pH7? Carboxylic acid terminus? AtPH 7, roughly what fraction of the entire peptide is in the state shown in (A)? he peptide reacts with acetyl chloride to form one main organic product. Draw the reaction, showing the mechanism using the arrow formalism. What type of reaction is this (max 2 words)? E. F. G. * At pH , how does the net charge of your product from (F) compare to that of the initial peptide in (C)? Instead of reacting the peptide with acetyl chloride, you instead add an enzyme that facilitates methylation of the amino terminus with S-adenosylmethionine (SAM) as the methyl donor. Draw monomethylation of the amino terminus by SAM using the arrow formalism (feel free to abbreviate any parts of the peptide not directly involved in the reaction as "peptide"). What type of reaction is this (max 2 words)? Which of the following classifiers best describes the reactive carbon involved in this reaction: methyl, primary, secondary, tertiary? You allow the methylation with SAM to continue until the amino terminus is no longer 1. J. K. L. nucleophilic. Draw the final product. 1. At pH 7, what fraction of your final product is in the state where every atom has zero formal charge?
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