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Ras oncogene

Ras oncogene

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The Ras oncogene is activated by mutation of its proto-oncogene precursor in about 30% of all human cancers. Use the dropdown menus to indicate yes or no for several possible genetic or epigenetic changes in the Ras gene, described below, to indicate whether you would you expect to find this change in tumor cells where one of the drivers is a Ras oncogene. Deletion of one copy of the gene ✓ [Select] N Y Methylation of CG dinucleotides [Select] A translocation that moves the coding region of Ras near a repressor DNA element such that Ras is not transcribed [Select] A missense mutation that causes Ras protein to be constitutively active (GTP- bound) in the absence of activating signals [Select] A copy number variant that locally amplifies the Ras gene [ Select] Acetylation of histones associated with the Ras gene [ Select]
Transcribed Image Text:The Ras oncogene is activated by mutation of its proto-oncogene precursor in about 30% of all human cancers. Use the dropdown menus to indicate yes or no for several possible genetic or epigenetic changes in the Ras gene, described below, to indicate whether you would you expect to find this change in tumor cells where one of the drivers is a Ras oncogene. Deletion of one copy of the gene ✓ [Select] N Y Methylation of CG dinucleotides [Select] A translocation that moves the coding region of Ras near a repressor DNA element such that Ras is not transcribed [Select] A missense mutation that causes Ras protein to be constitutively active (GTP- bound) in the absence of activating signals [Select] A copy number variant that locally amplifies the Ras gene [ Select] Acetylation of histones associated with the Ras gene [ Select]
The Ras oncogene is activated by mutation of its proto-oncogene precursor in about 30% of all human cancers. Use the dropdown menus to indicate yes or no for several possible genetic or epigenetic changes in the Ras gene, described below, to indicate whether you would you expect to find this change in tumor cells where one of the drivers is a Ras oncogene. Deletion of one copy of the gene [ Select] Methylation of CG dinucleotides in the promoter region [Select] A translocation that moves the coding region of Ras near a repressor DNA element such that Ras is not transcribed [Select ] A missense mutation that causes Ras protein to be constitutively active (GTP- bound) in the absence of activating signals [Select] A copy number variant that locally amplifies the Ras gene [Select] Acetylation of histones associated with the Ras gene ✓ [Select] N Y
Transcribed Image Text:The Ras oncogene is activated by mutation of its proto-oncogene precursor in about 30% of all human cancers. Use the dropdown menus to indicate yes or no for several possible genetic or epigenetic changes in the Ras gene, described below, to indicate whether you would you expect to find this change in tumor cells where one of the drivers is a Ras oncogene. Deletion of one copy of the gene [ Select] Methylation of CG dinucleotides in the promoter region [Select] A translocation that moves the coding region of Ras near a repressor DNA element such that Ras is not transcribed [Select ] A missense mutation that causes Ras protein to be constitutively active (GTP- bound) in the absence of activating signals [Select] A copy number variant that locally amplifies the Ras gene [Select] Acetylation of histones associated with the Ras gene ✓ [Select] N Y
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