R S N R S OH N E Z N Z N E HO E Z N R S OH N. R S N R S N .....

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### Lasonolide A: Stereochemical Configuration and Functional Groups

**Part a: Stereochemical Configuration**

Below is the molecular structure of Lasonolide A, a natural product known for its high cytotoxicity against various cancers. You are required to assign the stereochemical configuration of the selected tetrahedral carbon chiral centers and the alkene groups based on the following:

- **Chiral centers**: Assign as *R* or *S*. If not a chiral center, indicate as *N* (not a chiral center).
- **Alkene groups**: Assign as *E* (entgegen) or *Z* (zusammen). If not a stereocenter, indicate as *N* (neither).

The molecular structure diagram presents the Lasonolide A molecule with boxed areas around key atoms. Arrows point to these atoms, and labels (*R*, *S*, *E*, *Z*, or *N*) allow for notation of the stereochemistry. Not every chiral center or double bond requires assignment in this problem.

**Part b: Functional Groups**

Circle the functional groups present in Lasonolide A from the list below:

- Amine
- Alcohol
- Ether
- Aldehyde
- Ketone
- Ester
- Amide
- Carboxylic acid

By evaluating Lasonolide A’s structure, identify which of these functional groups are part of the molecule.
Transcribed Image Text:### Lasonolide A: Stereochemical Configuration and Functional Groups **Part a: Stereochemical Configuration** Below is the molecular structure of Lasonolide A, a natural product known for its high cytotoxicity against various cancers. You are required to assign the stereochemical configuration of the selected tetrahedral carbon chiral centers and the alkene groups based on the following: - **Chiral centers**: Assign as *R* or *S*. If not a chiral center, indicate as *N* (not a chiral center). - **Alkene groups**: Assign as *E* (entgegen) or *Z* (zusammen). If not a stereocenter, indicate as *N* (neither). The molecular structure diagram presents the Lasonolide A molecule with boxed areas around key atoms. Arrows point to these atoms, and labels (*R*, *S*, *E*, *Z*, or *N*) allow for notation of the stereochemistry. Not every chiral center or double bond requires assignment in this problem. **Part b: Functional Groups** Circle the functional groups present in Lasonolide A from the list below: - Amine - Alcohol - Ether - Aldehyde - Ketone - Ester - Amide - Carboxylic acid By evaluating Lasonolide A’s structure, identify which of these functional groups are part of the molecule.
Expert Solution
Step 1

To identify the configuration, number the four groups attached to a central carbon atom according to their atomic number. Higher atomic number elements get more priority. Inf the numbering goes in a clockwise direction then the configuration would be R and vice versa.

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