Questions The half-life of the drug was 6.93h, and the apparent volume of distribution was 100L. The drug had a strong first-pass effect. Its elimination in vivo included hepatic metabolism and renal excretion, and the renal excretion accounted for 20% of the elimination rate. The AUC of intravenous administration of 200mg of the drug was 20µg.h/mL.. When the drug was prepared as a tablet for oral administration, the AUC of 1000mg was 10µg.h/mL. 2. The absolute bioavailability of the drug tablet is A.10% B.20% C.40% D.50% E.80%

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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The half-life of the drug was 6.93h, and the apparent volume of
distribution was 100L. The drug had a strong first-pass effect. Its
elimination in vivo included hepatic metabolism and renal
excretion, and the renal excretion accounted for 20% of the
elimination rate. The AUC of intravenous administration of 200mg
of the drug was 20µg.h/mL.. When the drug was prepared as a
tablet for oral administration, the AUC of 1000mg was
10µg.h/mL.
2. The absolute bioavailability of the drug tablet is
A.10%
B.20%
C.40%
D.50%
E.80%
Transcribed Image Text:Questions The half-life of the drug was 6.93h, and the apparent volume of distribution was 100L. The drug had a strong first-pass effect. Its elimination in vivo included hepatic metabolism and renal excretion, and the renal excretion accounted for 20% of the elimination rate. The AUC of intravenous administration of 200mg of the drug was 20µg.h/mL.. When the drug was prepared as a tablet for oral administration, the AUC of 1000mg was 10µg.h/mL. 2. The absolute bioavailability of the drug tablet is A.10% B.20% C.40% D.50% E.80%
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