Questions about cholera - In modern outbreaks, it has been noted that taking a drug like Prilosec or Nexium (Omeprazole or Esomeprazole), which is a proton pump inhibitor, worsens the intensity of the Cholera bacteria and the chances of contracting it. Why might taking a proton pump inhibitor increase chances of contracting cholera? - A hallmark of Vibrio cholerae infection is profuse, isosmotic diarrhea sometimes said to resemble “rice water”. The toxin secreted by Vibrio cholerae is a protein complex with six subunits. Cholera toxin binds to intestinal cells, and the A subunit is taken into the enterocytes by endocytosis. Once inside the enterocyte, the toxin turns on adenylyl cyclase, which then produces cAMP continuously. Because the CFTR channel of the enterocyte is a cAMP-gated channel, the effect of cholera toxin is to open the CFTR channels and keep them open. Why would continuously open enterocyte CFTR channels cause secretory diarrhea and dehydration in humans?
Questions about cholera
- In modern outbreaks, it has been noted that taking a drug like Prilosec or Nexium (Omeprazole or Esomeprazole), which is a proton pump inhibitor, worsens the intensity of the Cholera bacteria and the chances of contracting it. Why might taking a proton pump inhibitor increase chances of contracting cholera?
- A hallmark of Vibrio cholerae infection is profuse, isosmotic diarrhea sometimes said to resemble “rice water”. The toxin secreted by Vibrio cholerae is a protein complex with six subunits. Cholera toxin binds to intestinal cells, and the A subunit is taken into the enterocytes by endocytosis. Once inside the enterocyte, the toxin turns on adenylyl cyclase, which then produces cAMP continuously. Because the CFTR channel of the enterocyte is a cAMP-gated channel, the effect of cholera toxin is to open the CFTR channels and keep them open. Why would continuously open enterocyte CFTR channels cause secretory diarrhea and dehydration in humans?
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