Questions 11-13 are all based on the following information: Human chromosome 4 is about 215 CM long. SNPs 1 and 2 are two single nucleotide polymorphic loci at opposite ends of this chromosome. Linked at 8 cM from SNP2 is a gene for a recessive form of hot water epilepsy (epilepsy induced by hot water poured on the head; H = healthy, h = epilepsy). The pedigree shows inheritance of the SNPs and of the disorder. SNP alleles were identified by allele- specific oligonucleotide hybridization (shading indicates hybridization). Assume that there is no new mutation or aberrant event in this pedigree. Healthy (HP) 1-1 GG TT TT II-1 AA CC GG TT 1-2 1-3 T 11-2 14 Female Male SNP1 Hot-water epilepsy (hh) H SNP2 8CM 11. Give the egg and sperm genotype (for all three loci) received by II-1 and II-2. No explanations needed. • Genotype of egg received by II-1: . Genotype of sperm received by Il-1: Genotype of egg received by II-2: • Genotype of sperm received by II-2: 12. Epilepsy question continued... A geneticist want to calculate the probability that the first child born to Il-1 and II-2 will have hot-water epilepsy and will also be homozygous at both SNP loci. (No explanations needed for any part of this question.) a. Give the required gamete genotype from II-1 (all three loci). b. Considering H/h and SNP1, is this gamete (from II-1) Parental type (P), Recombinant (R), or unknown status (U)? c. Considering H/h and SNP2, is this gamete (from Il-1) Parental type (P), Recombinant (R), or unknown status (U)? d. Now give the required gamete genotype from II-2 (all three loci). e. Considering H/h and SNP1, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? f. Considering H/h and SNP2, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? 13. Epilepsy question continued... To continue calculating the probability that II-1 and II-2 will have a child with hot- water epilepsy and homozygous for both SNPs... a. What is the probability of of the required gamete from II-1? Show the steps in your calculation. b. What is the probability of of the required gamete from II-2? Show the steps in your calculation. c. What is the overall probability of this child? (Just set up the equation, no need to calculate the final value.)
Questions 11-13 are all based on the following information: Human chromosome 4 is about 215 CM long. SNPs 1 and 2 are two single nucleotide polymorphic loci at opposite ends of this chromosome. Linked at 8 cM from SNP2 is a gene for a recessive form of hot water epilepsy (epilepsy induced by hot water poured on the head; H = healthy, h = epilepsy). The pedigree shows inheritance of the SNPs and of the disorder. SNP alleles were identified by allele- specific oligonucleotide hybridization (shading indicates hybridization). Assume that there is no new mutation or aberrant event in this pedigree. Healthy (HP) 1-1 GG TT TT II-1 AA CC GG TT 1-2 1-3 T 11-2 14 Female Male SNP1 Hot-water epilepsy (hh) H SNP2 8CM 11. Give the egg and sperm genotype (for all three loci) received by II-1 and II-2. No explanations needed. • Genotype of egg received by II-1: . Genotype of sperm received by Il-1: Genotype of egg received by II-2: • Genotype of sperm received by II-2: 12. Epilepsy question continued... A geneticist want to calculate the probability that the first child born to Il-1 and II-2 will have hot-water epilepsy and will also be homozygous at both SNP loci. (No explanations needed for any part of this question.) a. Give the required gamete genotype from II-1 (all three loci). b. Considering H/h and SNP1, is this gamete (from II-1) Parental type (P), Recombinant (R), or unknown status (U)? c. Considering H/h and SNP2, is this gamete (from Il-1) Parental type (P), Recombinant (R), or unknown status (U)? d. Now give the required gamete genotype from II-2 (all three loci). e. Considering H/h and SNP1, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? f. Considering H/h and SNP2, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? 13. Epilepsy question continued... To continue calculating the probability that II-1 and II-2 will have a child with hot- water epilepsy and homozygous for both SNPs... a. What is the probability of of the required gamete from II-1? Show the steps in your calculation. b. What is the probability of of the required gamete from II-2? Show the steps in your calculation. c. What is the overall probability of this child? (Just set up the equation, no need to calculate the final value.)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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