Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
What is the major product for the following reaction?
A
B
C
D
![**Question:** What is the major product for the following reaction?
![Chemical Reaction]
1) NaOEt
2) H⁺
Possible products:
**A:**
Structure: Cyclohexane ring with a hydroxyl group (OH) and ethoxy group (OEt) attached at alternating positions (trans).
**B:**
Structure: Cyclohexane ring with a hydroxyl group (OH) and ethoxy group (OEt) attached at the same position (cis).
**C:**
Structure: Cyclohexane ring with an ethoxy group (OEt) attached, no hydroxyl group.
**D:**
Structure: Cyclohexane ring with a hydroxyl group (OH) and ethoxy group (OEt) attached at alternating positions (trans).
From the conditions provided (1. NaOEt, 2. H⁺), one can infer that the reaction involves the formation of an intermediate followed by protonation. Identifying the major product would require understanding the mechanism and stability of potential intermediates and final compounds.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7e6a3bf8-d146-491a-b48e-eee1e364a845%2F9c5cb7a8-2ddb-4474-b8ad-f016425d73e3%2Fiz7kwb_processed.png&w=3840&q=75)
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