QUESTION 4 In the reaction catalyzed by Triose phosphate isomerase, formation of the enediol intermedia involves transfer of substrate. from substrate onto the enzyme and from the enzyme back onto th O Oxygen Electrons O Hydrogen bonds Phosphate O Protons
QUESTION 4 In the reaction catalyzed by Triose phosphate isomerase, formation of the enediol intermedia involves transfer of substrate. from substrate onto the enzyme and from the enzyme back onto th O Oxygen Electrons O Hydrogen bonds Phosphate O Protons
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
4

Transcribed Image Text:QUESTION 4
In the reaction catalyzed by Triose phosphate isomerase, formation of the enediol intermediate
involves transfer of
from substrate onto the enzyme and from the enzyme back onto the
substrate.
O Oxygen
Electrons
Hydrogen bonds
Phosphate
O Protons
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Step 1
- The enzyme is dimeric with a molecular weight of approximately 54kD.
- It mainly catalyzes the isomerization of a ketose dihydroxyacetone phosphate) to an aldose (glyceraldehyde phosphate) in glycolysis and gluconeogenesis pathway.
- It is also involved in other metabolic biological processes which include fatty acid biosynthesis and the HMP shunt pathway.
- Mutation of this enzyme results in an autosomal recessive disorder that leads to increased accumulation of dihydroxyacetone phosphate in the erythrocytes.
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