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QUESTION 4 - Dave left the unicorn business and so Kevin decided to combine his herd with Stuart's. As they have managed their herds and developed a breeding program for Pink Fluffy Unicorns, Kevin and Stuart have discovered a terrible condition that causes their pink fluffy unicorns to be born without a fluffy hair coat and without a unicorn. They hired Bob to help them with genetic testing and sequencing to try and identify the problem so they can address it in their plans. (Note: it's almost like someone made a minion movie, and the questions are being phrased in a way to make use of the available images of minions from the internet...weird). a. Kevin and Stuart believe they have found the mutation responsible for this terrible condition affecting a gene named FLUF1A. The levels of mRNA transcribed from this gene are very low in affected animals compared to unaffected. The variant identified is a SNP base pair substitution located in the response element for this gene. Explain to the minions what the response element is, what its role is in regulating the expression of FLUF1A, and how you might expect this mutation to have an impact on phenotype. (3 points) b. Stuart plans to irradiate (expose to radiation) the less fluffy unicorns with the hope of increasing fluffiness in their offspring. Kevin is convinced there is another way. Name and describe the two mechanisms that would allow Stuart to introduce new alleles and increase fluffiness in his unicorns. Do you recommend one approach more than the other? Why? (3 points) C. With Bob's help, Kevin and Stuart have received funding to sequence the pink fluffy unicorn genome. He's very excited but concerned because he must pick the best representative from his herd of fluffy unicorns to ensure a successful sequencing project. They have narrowed down to the choice to the following three unicorns: GENOME SEQUENCING CANDIDATES: Unicorn #1 Gender: Female Homozygosity: 33% UNICORN Unicorn #3 Gender: Male Homozygosity: 75% Unicorn #2 Gender: Female Homozygosity: 55% Which of the three unicorns above is the best candidate for providing the DNA for sequencing the unicorn genome? List the reasons and explain to Dave why they are important considerations. (4 points)

QUESTION 4 - Dave left the unicorn business and so Kevin decided to combine his herd with Stuart's. As they have managed their herds and developed a breeding program for Pink Fluffy Unicorns, Kevin and Stuart have discovered a terrible condition that causes their pink fluffy unicorns to be born without a fluffy hair coat and without a unicorn. They hired Bob to help them with genetic testing and sequencing to try and identify the problem so they can address it in their plans. (Note: it's almost like someone made a minion movie, and the questions are being phrased in a way to make use of the available images of minions from the internet...weird). a. Kevin and Stuart believe they have found the mutation responsible for this terrible condition affecting a gene named FLUF1A. The levels of mRNA transcribed from this gene are very low in affected animals compared to unaffected. The variant identified is a SNP base pair substitution located in the response element for this gene. Explain to the minions what the response element is, what its role is in regulating the expression of FLUF1A, and how you might expect this mutation to have an impact on phenotype. (3 points) b. Stuart plans to irradiate (expose to radiation) the less fluffy unicorns with the hope of increasing fluffiness in their offspring. Kevin is convinced there is another way. Name and describe the two mechanisms that would allow Stuart to introduce new alleles and increase fluffiness in his unicorns. Do you recommend one approach more than the other? Why? (3 points) C. With Bob's help, Kevin and Stuart have received funding to sequence the pink fluffy unicorn genome. He's very excited but concerned because he must pick the best representative from his herd of fluffy unicorns to ensure a successful sequencing project. They have narrowed down to the choice to the following three unicorns: GENOME SEQUENCING CANDIDATES: Unicorn #1 Gender: Female Homozygosity: 33% UNICORN Unicorn #3 Gender: Male Homozygosity: 75% Unicorn #2 Gender: Female Homozygosity: 55% Which of the three unicorns above is the best candidate for providing the DNA for sequencing the unicorn genome? List the reasons and explain to Dave why they are important considerations. (4 points)

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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QUESTION 4 - Dave left the unicorn business and so Kevin decided to combine his herd with Stuart's. As they have managed their herds and developed a breeding program for Pink Fluffy Unicorns, Kevin and Stuart have discovered a terrible condition that causes their pink fluffy unicorns to be born without a fluffy hair coat and without a unicorn. They hired Bob to help them with genetic testing and sequencing to try and identify the problem so they can address it in their plans. (Note: it's almost like someone made a minion movie, and the questions are being phrased in a way to make use of the available images of minions from the internet...weird). a. Kevin and Stuart believe they have found the mutation responsible for this terrible condition affecting a gene named FLUF1A. The levels of mRNA transcribed from this gene are very low in affected animals compared to unaffected. The variant identified is a SNP base pair substitution located in the response element for this gene. Explain to the minions what the response element is, what its role is in regulating the expression of FLUF1A, and how you might expect this mutation to have an impact on phenotype. (3 points) b. Stuart plans to irradiate (expose to radiation) the less fluffy unicorns with the hope of increasing fluffiness in their offspring. Kevin is convinced there is another way. Name and describe the two mechanisms that would allow Stuart to introduce new alleles and increase fluffiness in his unicorns. Do you recommend one approach more than the other? Why? (3 points) C. With Bob's help, Kevin and Stuart have received funding to sequence the pink fluffy unicorn genome. He's very excited but concerned because he must pick the best representative from his herd of fluffy unicorns to ensure a successful sequencing project. They have narrowed down to the choice to the following three unicorns: GENOME SEQUENCING CANDIDATES: Unicorn #1 Gender: Female Homozygosity: 33% UNICORN Unicorn #3 Gender: Male Homozygosity: 75% Unicorn #2 Gender: Female Homozygosity: 55% Which of the three unicorns above is the best candidate for providing the DNA for sequencing the unicorn genome? List the reasons and explain to Dave why they are important considerations. (4 points)
Transcribed Image Text:QUESTION 4 - Dave left the unicorn business and so Kevin decided to combine his herd with Stuart's. As they have managed their herds and developed a breeding program for Pink Fluffy Unicorns, Kevin and Stuart have discovered a terrible condition that causes their pink fluffy unicorns to be born without a fluffy hair coat and without a unicorn. They hired Bob to help them with genetic testing and sequencing to try and identify the problem so they can address it in their plans. (Note: it's almost like someone made a minion movie, and the questions are being phrased in a way to make use of the available images of minions from the internet...weird). a. Kevin and Stuart believe they have found the mutation responsible for this terrible condition affecting a gene named FLUF1A. The levels of mRNA transcribed from this gene are very low in affected animals compared to unaffected. The variant identified is a SNP base pair substitution located in the response element for this gene. Explain to the minions what the response element is, what its role is in regulating the expression of FLUF1A, and how you might expect this mutation to have an impact on phenotype. (3 points) b. Stuart plans to irradiate (expose to radiation) the less fluffy unicorns with the hope of increasing fluffiness in their offspring. Kevin is convinced there is another way. Name and describe the two mechanisms that would allow Stuart to introduce new alleles and increase fluffiness in his unicorns. Do you recommend one approach more than the other? Why? (3 points) C. With Bob's help, Kevin and Stuart have received funding to sequence the pink fluffy unicorn genome. He's very excited but concerned because he must pick the best representative from his herd of fluffy unicorns to ensure a successful sequencing project. They have narrowed down to the choice to the following three unicorns: GENOME SEQUENCING CANDIDATES: Unicorn #1 Gender: Female Homozygosity: 33% UNICORN Unicorn #3 Gender: Male Homozygosity: 75% Unicorn #2 Gender: Female Homozygosity: 55% Which of the three unicorns above is the best candidate for providing the DNA for sequencing the unicorn genome? List the reasons and explain to Dave why they are important considerations. (4 points)
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