Question 3 (12 marks) We intend to design a system for optimal control (u₁(t), u2(t)) which represent the Tuberculosis (TB) treatment rates for latent class and infectious class, respectively. Our target is to minimize the TB infected individuals (including latent and infectious individuals) as well as the costs required to con- trol TB by treating latent and infectious individuals, over a certain time horizon [0,t]. The cost of each intervention is assumed to be proportional to the square of its intensity. Thus we formulate the optimization problem below. Minimize the objective function J(u1(.), u2(.) = " A₁E(t) + A21(t) + B¹u²(t) + ¹²u²(t) 1 subject to d.S = dt dV A(1 p) BSI+kV-ds, =Ap-kVdV, dt dE = dt BSI (u(t) +e+d)E+OR, dI == EE (d-8-u2(t))I, dt dR = u(t)Eu₂(t) (d+0)R dt S(0) So≥0, V(0) = Vo≥ 0, E(0) = Eo ≥ 0,1(0) = 10 ≥0, R(0) = Ro≥ 0. The control variables are assumed to be bounded: Given any t > 0, 0(t) b₁ and 0 < u2(t)
Question 3 (12 marks) We intend to design a system for optimal control (u₁(t), u2(t)) which represent the Tuberculosis (TB) treatment rates for latent class and infectious class, respectively. Our target is to minimize the TB infected individuals (including latent and infectious individuals) as well as the costs required to con- trol TB by treating latent and infectious individuals, over a certain time horizon [0,t]. The cost of each intervention is assumed to be proportional to the square of its intensity. Thus we formulate the optimization problem below. Minimize the objective function J(u1(.), u2(.) = " A₁E(t) + A21(t) + B¹u²(t) + ¹²u²(t) 1 subject to d.S = dt dV A(1 p) BSI+kV-ds, =Ap-kVdV, dt dE = dt BSI (u(t) +e+d)E+OR, dI == EE (d-8-u2(t))I, dt dR = u(t)Eu₂(t) (d+0)R dt S(0) So≥0, V(0) = Vo≥ 0, E(0) = Eo ≥ 0,1(0) = 10 ≥0, R(0) = Ro≥ 0. The control variables are assumed to be bounded: Given any t > 0, 0(t) b₁ and 0 < u2(t)
Linear Algebra: A Modern Introduction
4th Edition
ISBN:9781285463247
Author:David Poole
Publisher:David Poole
Chapter2: Systems Of Linear Equations
Section2.4: Applications
Problem 23EQ:
23. Consider a simple economy with just two industries: farming and manufacturing. Farming consumes...
Related questions
Question
Can you please provide a full solution for this problem
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps with 2 images
Recommended textbooks for you
Linear Algebra: A Modern Introduction
Algebra
ISBN:
9781285463247
Author:
David Poole
Publisher:
Cengage Learning
Linear Algebra: A Modern Introduction
Algebra
ISBN:
9781285463247
Author:
David Poole
Publisher:
Cengage Learning