Question 2: НО. HO,,, HO OH Salicilin HO Salicilin is the natural precursor of Aspirin (Acetyl Salicylic Acid). Aspirin synthesis (shown in the scheme below) begins with the hydrolytic release of Salicylic Alcohol from Salicilin under acidic conditions. After oxidation, Salicylic Acid is then acetylated to produce Aspirin. Acidic Hydrolysis HO HO HO Salicylic Alcohol НО. HO,,. Xp= OH HO Salicilin HO O OH Salicylic Acid Oxidation HO a) Provide a detailed arrow-pushing mechanism showing the release of Salicylic Alcohol from Salicilin. H₂O, H+ OH Salicylic Acid 4.9 HO HO Acetylation Salicylic Alcohol + НО. & HO,,, HO Aspirin b) In the empty box, provide appropriate reagents and reaction conditions necessary to convert Salicylic Acid to Aspirin. OH Aspirin OH OH Glucose OH

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Catalysis and Enzymatic Reactions

Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.

Lock And Key Model

The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.