Question 1: In the early 1960s, retroviruses were determined to cause many avian cancers. As a result, nucleic acid analogs as potential antiviral compounds were tested against various human cancer cells. Since this retrovirus theory did not pan out in human cancers, many potential drugs were shelved. However, in the 1980s, a new retrovirus, HIV, became a major focus of drug discovery, or re-discovery in this case. Zidovudine, or 5-azidothymidine (AZT), was found to be a very potent inhibitor of HIV, and quickly became an indispensable part of HIV treatment, and remains so to this day. AZT works by being incorporated into a new viral DNA chain. However, the N3 group (an azide group) prevents the next connection, effectively stopping the DNA synthesis. Assign all stereocenters as R or S. C HO to product dist Huon NH N= .... AZT 5-azidothymidine oxyge tee as can
Neutral Amino Acids
Amino acids which do not have any charge on them are neutral amino acids.
Globular Protein
The globular proteins refer to the shape of protein specifically spherical in nature apart from spherical form fibrous, disordered and membrane-bound proteins exist. These globular proteins are miscible in water and form a colloidal solution rather than other types which might not exhibit solubility. Many classes of the fold are found in globular proteins, which render them a sphere shape. Globular fold containing proteins usually are referred to by the term globin.
Dimer
Dimers are basic organic compounds, which are derivates of oligomers. It is formed by the combination of two monomers which could potentially be strong or weak and in most cases covalent or intermolecular in nature. Identical monomers are called homodimer, the non-identical dimers are called heterodimer. The method by which dimers are formed is known as “dimerization”.
Dipeptide
A dipeptide is considered a mixture of two distinct amino acids. Since the amino acids are distinct, based on their composition, two dipeptide's isomers can be produced. Various dipeptides are biologically essential and are therefore crucial to industry.
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