**Question 9:**Voxelotor’s structure is shown below. What would you expect the overall charge of the molecule to be in the blood (pH = 7.4)?- **Pyridinium pKₐ = 2.6**- **Phenol pKₐ = 8.3****Diagram Explanation:**The image shows the chemical structure of Voxelotor. It features a pyridinium moiety and a phenol group. The pyridinium is characterized by a nitrogen atom within a six-membered aromatic ring, indicating it carries a positive charge under standard conditions. The phenol group is composed of a hydroxyl group (-OH) attached to an aromatic ring.In the blood, at pH 7.4, we analyze the protonation states:- The pyridinium group (pKₐ = 2.6) will remain protonated and positively charged because the pH is greater than the pKₐ.- The phenol group (pKₐ = 8.3) will mostly remain uncharged (non-ionized) because the pH is lower than the pKₐ.Therefore, at physiological pH (7.4), Voxelotor would have an overall positive charge due to the protonated pyridinium group.

An acidic molecule is deprotonated at a pH greater than the pKa value. Given the pyridinium(R-NH+)…

Answered: Q9: Voxelotor's structure is shown…

Q9: Voxelotor's structure is shown below. What would you expect the overall charge of the molecule to be in the blood (pH = 7.4) %3D Pyridinium pka = 2.6 Phenol pka = 8.3 %3D H, N, OH

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Mass Spectrometry

This process is an instrumental method in which a sample is changed to fast moving positive ions by electron bombardment. The charged particles vary due to their different mass to charge ratio and are estimated with the help of this difference. It is also called mass spectroscopy.

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