Q6. This figure shows the sequence alignment of five (5) different Src homology 2 (SH2) domains, all from different species. BB BC BD BE BF aB1 aA aB2 C.g. 1250 HRVINHPYYFPINGKOAEDYLRSKERGDFVIROSSRGDDHLAITNKLDKDLFOHVDIOELEKENPLALGKVLVVEG- S.c. 1251 HRVINHPYYFPFNGROAEDYLRSKERGEFVIROSSRGDDHLVITWKLDKDLFOHIDIOELEKENPLALGKVLIVDN-- QRYHDLDQIIVEYLONKIRLLNELT -QKYNDLDQIIVEYLONKVRLLNEMT S.p. 1162 ARVIKHPLEKDLNASQAEAYLSKMOVGDLVIRPSSKGSDHIVVTWKVAEGSYOHIDVLELEKENEFTIGOKLLVKGRFEKMTYQYSDLDELIVLHIKAIAKKIDEMC EEFEDLDEIIARHIMPMALAARELI EEFEDLDEIVARYVOPMASFARDLL D.m. 1332 RRVIAHPSFFNKSYAEVVAMLAEADOGEVALRPSSKSKOHTATWKVADDIFOHIDVREEGKENDFSLGRSLNIGT---- 8.s. 1327 KRVIAHPSEHNINFKOAEKMMETMDOGDVIIRPSSKGENHLTVENKVSDGIYOHVDVREEGKENAFSLGATLNINS- A AAA R1281 These five domains are likely to: have arisen from gene duplication and then DNA segment shuffling. be derived from different ancestral proteins. show less than 25% sequence identity. be the result of lateral gene transfer followed by intragenic mutation.

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