Q14) Exercise 3 on the following pages is referring to a disputed 2010 study claiming that bacteria isolated from Mono Lake ([As] = 200 µM, more than 1000x the legal limit in drinking water) can substitute As instead of P into its DNA. Skeptical of the textbook's framing on this, you find the following data in which the free energy profiles for hydrolysis of As and P esters through two transition states are predicted by computational methods. Based on your knowledge of chemical kinetics and DNA structure, why do you think it is unlikely that organisms use As in place of P?
Q14) Exercise 3 on the following pages is referring to a disputed 2010 study claiming that bacteria isolated from Mono Lake ([As] = 200 µM, more than 1000x the legal limit in drinking water) can substitute As instead of P into its DNA. Skeptical of the textbook's framing on this, you find the following data in which the free energy profiles for hydrolysis of As and P esters through two transition states are predicted by computational methods. Based on your knowledge of chemical kinetics and DNA structure, why do you think it is unlikely that organisms use As in place of P?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Please help me.
![Q14) Exercise 3 on the following pages is referring to a disputed 2010 study claiming
that bacteria isolated from Mono Lake ([As] = 200 µM, more than 1000x the legal limit in
drinking water) can substitute As instead of P into its DNA.
Skeptical of the textbook's framing on this, you find the following data in which the free
energy profiles for hydrolysis of As and P esters through two transition states are
predicted by computational methods. Based on your knowledge of chemical kinetics
and DNA structure, why do you think it is unlikely that organisms use As in place of P?
TS1
TS1
E, kcalimol
но-
40
но
HO
O-H
35
35
30
kcal/mol
25
20
20
X- As, P
kcal/mol
15
10
5
НО—R
6-x=0](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fddf9416b-4a06-4830-bb90-9618a5b03489%2F5490826a-ed1e-46b3-8071-f0c9a6eb08e5%2Fm040i9p_processed.png&w=3840&q=75)
Transcribed Image Text:Q14) Exercise 3 on the following pages is referring to a disputed 2010 study claiming
that bacteria isolated from Mono Lake ([As] = 200 µM, more than 1000x the legal limit in
drinking water) can substitute As instead of P into its DNA.
Skeptical of the textbook's framing on this, you find the following data in which the free
energy profiles for hydrolysis of As and P esters through two transition states are
predicted by computational methods. Based on your knowledge of chemical kinetics
and DNA structure, why do you think it is unlikely that organisms use As in place of P?
TS1
TS1
E, kcalimol
но-
40
но
HO
O-H
35
35
30
kcal/mol
25
20
20
X- As, P
kcal/mol
15
10
5
НО—R
6-x=0
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