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- 10- 00 O SCNSA-SCN10A CDKN1A HANDI VTI1A SYTI • MYOCD 9 10 11 12 13 14 15 16 17 18 19 20 2122 X YQ2) А. As long as the optimum dosage of the ionizing radiation is achieved it can be used for treatment of cancer. Can you explain the working principle of the treatment? - Hint: Consider the effect of treatment on both healthy and cancer cells В. Please explain how DNA viruses and telomere shortening may cause the onset of cancer.Q38. The ΔF508 mutation of the CFTR gene is the cause of most cases of cystic fibrosis (CF). One focus of research into a cure for CF is "gene therapy" — inserting normal copies of the CFTR gene into the cells of CF patients. Which of the following areas of CF research is most likely to improve symptoms for CF patients? A. Inserting extra copies of genes that code for the proteosome. B. Studying the chaperone proteins of the endoplasmic reticulum (ER). C. Improving the lung function of people who are carriers of the CF allele (Cc). D. Stabilizing the plasma membrane were the ΔF508 form of the protein accumulates.
- Panswer Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the phenotype of cancer (stem?) cells.?explain the most likely steps of what might happen inside a MDA-MB-231 cell after it is exposed to UV light.The p53 protein was discovered through its association with SV40 T antigen and assumed initially to be an oncoprotein. a. What is the current consensus as the function of p53 and what evidence caused this change in view? b. How does the effect of mutation in the p53 gene differ from the effect of mutation in the RB gene what is the molecular basis for this difference ?
- What percentage of cells in an organ or a tissue need toexpress a therapeutic gene to alleviate the effects of agenetic disorder?1. How can stem cell treatment help the covid-19 patients? 2. How do ventilator help to rescue the patient with acute and chronic respiratory failures?Discuss the principles that govern the presence and maintenance of stem cells both in vivo and in vitro.
- Our understanding of the molecular biology of cancer formation has been greatly enhanced by studying oncogenic viruses. Answer the following questions regarding oncogenic retroviruses? Explain how a gain of function mutation in the Ras protein caused by a retrovirus might lead to cancer formation.1) Briefly outline the location, isolation , characterisation, benefits, and limitations of adult stem cells in TERM 2) Describe and compare the various potencies exhibited by stem cell pheno type 3) Outline the in vitro/in vivo mechanical forces that can be used to influence the quality of cell response and tissue formation obtained by TE..Skin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.
