Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR, new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use.

icon
Related questions
Question
100%

1. I need help with assessing what this means in layman's terminology - (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19)?

2. (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48) ?

3. (0.7% vs. 1.3%; P=0.04; NNH=166) ?

 

Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without
T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR,
new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with
reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with
dapagliflozin use.
Transcribed Image Text:Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR, new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use.
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer