Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR, new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use.

MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
100%

1. I need help with assessing what this means in layman's terminology - (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19)?

2. (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48) ?

3. (0.7% vs. 1.3%; P=0.04; NNH=166) ?

 

Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without
T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR,
new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with
reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with
dapagliflozin use.
Transcribed Image Text:Published in 2020, the Dapagliflozin in Chronic Kidney Disease (DAPA-CKD) randomized 4,304 patients with CKD (defined by eGFR of 25 to 75 and albuminuria with ACR of 200 to 5000 mg/g) with and without T2DM to dapagliflozin or placebo. The study was halted early after an interim safety analysis found evidence of benefit as dapagliflozin was found to reduce the composite endpoint of decline of ≥50% in eGFR, new ESRD, renal mortality, or CVD mortality (9.2% vs. 14.5%; HR 0.61; 95% CI 0.51-0.72; NNT=19). Importantly, this benefit was similar regardless of T2DM status. The medication was also associated with reduction in other endpoints, including all-cause mortality (4.7% vs. 6.8%; 0.69; 0.53-0.88; NNT=48). There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use.
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
MATLAB: An Introduction with Applications
MATLAB: An Introduction with Applications
Statistics
ISBN:
9781119256830
Author:
Amos Gilat
Publisher:
John Wiley & Sons Inc
Probability and Statistics for Engineering and th…
Probability and Statistics for Engineering and th…
Statistics
ISBN:
9781305251809
Author:
Jay L. Devore
Publisher:
Cengage Learning
Statistics for The Behavioral Sciences (MindTap C…
Statistics for The Behavioral Sciences (MindTap C…
Statistics
ISBN:
9781305504912
Author:
Frederick J Gravetter, Larry B. Wallnau
Publisher:
Cengage Learning
Elementary Statistics: Picturing the World (7th E…
Elementary Statistics: Picturing the World (7th E…
Statistics
ISBN:
9780134683416
Author:
Ron Larson, Betsy Farber
Publisher:
PEARSON
The Basic Practice of Statistics
The Basic Practice of Statistics
Statistics
ISBN:
9781319042578
Author:
David S. Moore, William I. Notz, Michael A. Fligner
Publisher:
W. H. Freeman
Introduction to the Practice of Statistics
Introduction to the Practice of Statistics
Statistics
ISBN:
9781319013387
Author:
David S. Moore, George P. McCabe, Bruce A. Craig
Publisher:
W. H. Freeman